CXCL8 in thyroid disease: From basic notions to potential applications in clinical practice

Mario Rotondi, Francesca Coperchini, Luca Chiovato

Research output: Contribution to journalArticlepeer-review


CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting results. Solid evidences support a role of CXCL8 as a tumor-promoting agent in several human cancers. Studies in thyroid cancer are still in their initial stage, but promising. Several evidences indicate that thyroid cancer may share with other human malignancies some of the effects of CXCL8 and highlight the possibility of using CXCL8 as a marker of aggressiveness. Basic and clinical evidences in favor or against a role for CXCL8 in thyroid diseases are discussed.

Original languageEnglish
Pages (from-to)539-546
Number of pages8
JournalCytokine and Growth Factor Reviews
Issue number6
Publication statusPublished - Dec 2013


  • Autoimmune thyroid disease
  • Chemokines
  • CXCL8
  • Thyrocytes
  • Thyroid cancer

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)


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