Abstract
Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 6215-6217 |
| Number of pages | 3 |
| Journal | Journal of Virology |
| Volume | 72 |
| Issue number | 7 |
| Publication status | Published - Jul 1998 |
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ASJC Scopus subject areas
- Immunology
Cite this
CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection : Lack of association with mutations other than CCR5-Δ32. / Cohen, Oren J.; Paolucci, Stefania; Bende, Steven M.; Daucher, Marybeth; Moriuchi, Hiroyuki; Moriuchi, Masako; Cicala, Claudia; Davey, Richard T.; Baird, Barbara; Fauci, Anthony S.
In: Journal of Virology, Vol. 72, No. 7, 07.1998, p. 6215-6217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection
T2 - Lack of association with mutations other than CCR5-Δ32
AU - Cohen, Oren J.
AU - Paolucci, Stefania
AU - Bende, Steven M.
AU - Daucher, Marybeth
AU - Moriuchi, Hiroyuki
AU - Moriuchi, Masako
AU - Cicala, Claudia
AU - Davey, Richard T.
AU - Baird, Barbara
AU - Fauci, Anthony S.
PY - 1998/7
Y1 - 1998/7
N2 - Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.
AB - Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.
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UR - http://www.scopus.com/inward/citedby.url?scp=18244415985&partnerID=8YFLogxK
M3 - Article
VL - 72
SP - 6215
EP - 6217
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 7
ER -