CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection

Lack of association with mutations other than CCR5-Δ32

Oren J. Cohen, Stefania Paolucci, Steven M. Bende, Marybeth Daucher, Hiroyuki Moriuchi, Masako Moriuchi, Claudia Cicala, Richard T. Davey, Barbara Baird, Anthony S. Fauci

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.

Original languageEnglish
Pages (from-to)6215-6217
Number of pages3
JournalJournal of Virology
Volume72
Issue number7
Publication statusPublished - Jul 1998

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HIV infections
Genetic Polymorphisms
Virus Diseases
Human immunodeficiency virus
HIV
genetic polymorphism
mutation
Point Mutation
Mutation
point mutation
Amino Acid Sequence
amino acid sequences
assays

ASJC Scopus subject areas

  • Immunology

Cite this

CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection : Lack of association with mutations other than CCR5-Δ32. / Cohen, Oren J.; Paolucci, Stefania; Bende, Steven M.; Daucher, Marybeth; Moriuchi, Hiroyuki; Moriuchi, Masako; Cicala, Claudia; Davey, Richard T.; Baird, Barbara; Fauci, Anthony S.

In: Journal of Virology, Vol. 72, No. 7, 07.1998, p. 6215-6217.

Research output: Contribution to journalArticle

Cohen, OJ, Paolucci, S, Bende, SM, Daucher, M, Moriuchi, H, Moriuchi, M, Cicala, C, Davey, RT, Baird, B & Fauci, AS 1998, 'CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: Lack of association with mutations other than CCR5-Δ32', Journal of Virology, vol. 72, no. 7, pp. 6215-6217.
Cohen, Oren J. ; Paolucci, Stefania ; Bende, Steven M. ; Daucher, Marybeth ; Moriuchi, Hiroyuki ; Moriuchi, Masako ; Cicala, Claudia ; Davey, Richard T. ; Baird, Barbara ; Fauci, Anthony S. / CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection : Lack of association with mutations other than CCR5-Δ32. In: Journal of Virology. 1998 ; Vol. 72, No. 7. pp. 6215-6217.
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