CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: Lack of association with mutations other than CCR5-Δ32

Oren J. Cohen, Stefania Paolucci, Steven M. Bende, Marybeth Daucher, Hiroyuki Moriuchi, Masako Moriuchi, Claudia Cicala, Richard T. Davey, Barbara Baird, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Δ32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Δ32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.

Original languageEnglish
Pages (from-to)6215-6217
Number of pages3
JournalJournal of Virology
Volume72
Issue number7
Publication statusPublished - Jul 1998

ASJC Scopus subject areas

  • Immunology

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