CXCR4-CXCL12 and VEGF correlate to uveal melanoma progression

Renato Franco, Gerardo Botti, Massimo Mascolo, Giovanna Loquercio, Giuseppina Liguori, Gennaro Ilardi, Simona Losito, Anna La Mura, Rosa Calemma, Caterina Ieranò, Jane Bryce, Crescenzo D'Alterio, Stefania Scala

Research output: Contribution to journalArticlepeer-review


Despite improvements in early diagnosis of uveal melanoma, prognosis is still poor due to metastases development. Neoangiogenesis and migration are requisites to metastasis promotion. Cross-talking between CXCR4- CXCL12 axis and the VEGF pathway was shown to favours tumour progression. CXCR4-CXCL12-VEGF expression was evaluated by immunohistochemistry in 53 selected cases of primary uveal melanoma and in liver melanoma metastases. CXCR4 protein was detected in 41.4% cases, CXCL12 in 43.4% cases and VEGF expression in 39.6% cases. A significant correlation was found between CXCR4 and VEGF expression (p=0.011), CXCL12 and both tumour dimension and (p=0.006) and epithelioid-mixed cytotype (p=0.012). The two cases of uveal melanoma liver metastases in our series showed CXCR4 expression, weak immunoreactivity for CXCL12 and absent VEGF immunostaining. These data indicate that CXCR4-CXCL12 axis and its cross-talking with VEGF plays a role in uveal melanoma metastases and may be new prognostic markers in UMM. Moreover, these results suggest that targeted inhibition of CXCR4 could be introduced to control metastasis development in UMM.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number1
Publication statusPublished - Jan 1 2010


  • CXCL12
  • CXCR4
  • Uveal Melanoma
  • VEGF

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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