CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production

Nadia Caccamo, Luca Battistini, Marc Bonneville, Fabrizio Poccia, Jean Jacques Fournié, Serena Meraviglia, Giovanna Borsellino, Richard A. Kroczek, Carmela La Mendola, Emmanuel Scotet, Francesco Dieli, Alfredo Salerno

Research output: Contribution to journalArticlepeer-review

Abstract

Vγ9Vδ2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.

Original languageEnglish
Pages (from-to)5290-5295
Number of pages6
JournalJournal of Immunology
Volume177
Issue number8
Publication statusPublished - Oct 15 2006

ASJC Scopus subject areas

  • Immunology

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