Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali

Translated title of the contribution: Cyberknife frameless stereotactic radiosurgery for spinal lesions

M. Marchetti, I. Milanesi, L. Bianchi, M. Possanzini, L. Brait, G. Broggi, L. Fariselli

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Conventional EBRT lacks the precision necessary to allow delivery of large dose of radiation near radiosensitive structure such as the spinal cord. If the radiation dose could be confined more precisely to the treatment volume the likelihood of successful increase and the risk of spinal cord injury is minimized. We report our experience with Cyberknife. MATERIAL AND METHODS: Between August 2004 to May 2006 some selected patients who referred to "Fondazione INNC Besta" with presence of spinal lesions, underwent Cyberknife treatment. In all cases the lesions were tracked with implanted gold markers. Radiation dose plans were based on CT scans acquired using 1.25 mm slices. Planning Tumor Volume (PTV) was defined as the radiographic tumor volume with no margin. All patients were clinically and radiologically evaluated before and after treatment. In particular patients were investigated about pain and quality of life. RESULTS: All patients well tolerated the procedure. No acute radiation -induced toxicity was observed. The mean of tumor volume was 61,9 cc (range: 0,6-800 cc). The mean HI (Homogeneity Index) was 1,34 and the mean NCI (New Conformality Index) was 1,42. We observed a significantly pain relief. Quality of life improved during the first three months, but patients with a metastatic disease, afterwards, experienced a new worsening. CONCLUSION: Spinal frameless stereotactic radiosurgery was found to be feasible and safe. Cyberknife offers an alternative therapeutic modality in the palliation of pain with a benefit in quality of life. Anyway a larger series and a longer period of follow up are necessary to determinate late effects and the true tumor control rates.

Original languageItalian
Pages (from-to)263-268
Number of pages6
JournalRivista Medica
Volume13
Issue number1
Publication statusPublished - Mar 2007

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Radiosurgery
Tumor Burden
Radiation
Quality of Life
Pain
Therapeutics
Spinal Cord Injuries
Gold
Spinal Cord
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Marchetti, M., Milanesi, I., Bianchi, L., Possanzini, M., Brait, L., Broggi, G., & Fariselli, L. (2007). Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali. Rivista Medica, 13(1), 263-268.

Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali. / Marchetti, M.; Milanesi, I.; Bianchi, L.; Possanzini, M.; Brait, L.; Broggi, G.; Fariselli, L.

In: Rivista Medica, Vol. 13, No. 1, 03.2007, p. 263-268.

Research output: Contribution to journalArticle

Marchetti, M, Milanesi, I, Bianchi, L, Possanzini, M, Brait, L, Broggi, G & Fariselli, L 2007, 'Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali', Rivista Medica, vol. 13, no. 1, pp. 263-268.
Marchetti M, Milanesi I, Bianchi L, Possanzini M, Brait L, Broggi G et al. Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali. Rivista Medica. 2007 Mar;13(1):263-268.
Marchetti, M. ; Milanesi, I. ; Bianchi, L. ; Possanzini, M. ; Brait, L. ; Broggi, G. ; Fariselli, L. / Radiochirurgia stereotassica frameless con Cyberknife per il trattamento dei tumori spinali. In: Rivista Medica. 2007 ; Vol. 13, No. 1. pp. 263-268.
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