Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep

Raffaele Ferri, Liborio Parrino, Arianna Smerieri, Mario G. Terzano, Maurizio Elia, Sebastiano A. Musumeci, Salvatore Pettinato

Research output: Contribution to journalArticle

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Abstract

The natural arousal rhythm of non-rapid eye movement (NREM) sleep is known as the cyclic alternating pattern (CAP), which consists of arousal-related phasic events (Phase A) that periodically interrupt the tonic theta/delta activities of NREM sleep (Phase B). The complementary condition, i.e. non-CAP (NCAP), consists of a rhythmic electroencephalogram background with few, randomly distributed arousal-related phasic events. Recently, some relation between CAP and autonomic function has been preliminarily reported during sleep in young adults by means of spectral analysis of heart rate variability (HRV). The present study was aimed at analysing the effects of CAP on HRV in a group of normal children and adolescents. Six normal children and adolescents (age range 10.0-17.5 y) were included in this study. All-night polygraphic recordings were performed after adaptation to the sleep laboratory. Six 5-min epochs were selected from sleep Stage 2 and six from Stages 3 and 4 (slow-wave sleep), both in CAP and NCAP conditions. From such epochs, a series of parameters describing HRV was then calculated, in both time and frequency domains, on the electrocardiographic R-R intervals. Statistical comparison between CAP and NCAP epochs revealed a significant difference for most of the frequency domain parameters (increase of the low-frequency band, increase of the low-frequency/high-frequency ratio and decrease in the high-frequency band during CAP) both in Stage 2 and in slow-wave sleep. Our results demonstrate that the physiological fluctuations of arousal during sleep described as CAP are accompanied by subtle, but significant, changes in balance between the sympathetic and vagal components of the autonomic system.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalJournal of Sleep Research
Volume9
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Sleep
Heart Rate
Arousal
Eye Movements
Sleep Stages
Young Adult
Electroencephalography

Keywords

  • Autonomic function
  • Cyclic alternating pattern
  • Heart rate
  • Sleep
  • Spectral analysis
  • Variability

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. / Ferri, Raffaele; Parrino, Liborio; Smerieri, Arianna; Terzano, Mario G.; Elia, Maurizio; Musumeci, Sebastiano A.; Pettinato, Salvatore.

In: Journal of Sleep Research, Vol. 9, No. 1, 2000, p. 13-18.

Research output: Contribution to journalArticle

Ferri, Raffaele ; Parrino, Liborio ; Smerieri, Arianna ; Terzano, Mario G. ; Elia, Maurizio ; Musumeci, Sebastiano A. ; Pettinato, Salvatore. / Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. In: Journal of Sleep Research. 2000 ; Vol. 9, No. 1. pp. 13-18.
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