Cyclin T: Three forms for different roles in physiological and pathological functions

Antonio De Luca, Maria De Falco, Alfonso Baldi, Marco G. Paggi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cyclins are members of family of proteins involved in the cell cycle regulation. They are regulatory subunits of complexes with proteins called cyclin-dependent kinases (CDKs). There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b. All cyclin T contain an N-terminal "cyclin homology box," the most conserved region among different members of the cyclin family that serves to bind CDK9. In addition to the N-terminal cyclin domain, cyclin T contains a putative coiled-coil motif, a His-rich motif, and a C-terminal PEST sequence. The CDK9/cyclin T complex is able to activate gene expression in a catalytic-dependent manner, phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. In addition, only cyclin T1 supports interactions between Tat and TAR. The interaction of Tat with cyclin T1 alters the conformation of Tat to enhance the affinity and specificity of the Tat:TAR interaction. On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalJournal of Cellular Physiology
Volume194
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

Fingerprint

Cyclin T
Cyclins
Cells
Cyclin-Dependent Kinases
RNA Polymerase II
Gene expression
Muscle Cells
Muscle
Conformations
Cell Cycle
Gene Expression

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Cyclin T : Three forms for different roles in physiological and pathological functions. / De Luca, Antonio; De Falco, Maria; Baldi, Alfonso; Paggi, Marco G.

In: Journal of Cellular Physiology, Vol. 194, No. 2, 01.02.2003, p. 101-107.

Research output: Contribution to journalArticle

De Luca, Antonio ; De Falco, Maria ; Baldi, Alfonso ; Paggi, Marco G. / Cyclin T : Three forms for different roles in physiological and pathological functions. In: Journal of Cellular Physiology. 2003 ; Vol. 194, No. 2. pp. 101-107.
@article{5fe86aaeb0584a83af2569b7fa5c27f4,
title = "Cyclin T: Three forms for different roles in physiological and pathological functions",
abstract = "Cyclins are members of family of proteins involved in the cell cycle regulation. They are regulatory subunits of complexes with proteins called cyclin-dependent kinases (CDKs). There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b. All cyclin T contain an N-terminal {"}cyclin homology box,{"} the most conserved region among different members of the cyclin family that serves to bind CDK9. In addition to the N-terminal cyclin domain, cyclin T contains a putative coiled-coil motif, a His-rich motif, and a C-terminal PEST sequence. The CDK9/cyclin T complex is able to activate gene expression in a catalytic-dependent manner, phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. In addition, only cyclin T1 supports interactions between Tat and TAR. The interaction of Tat with cyclin T1 alters the conformation of Tat to enhance the affinity and specificity of the Tat:TAR interaction. On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells.",
author = "{De Luca}, Antonio and {De Falco}, Maria and Alfonso Baldi and Paggi, {Marco G.}",
year = "2003",
month = "2",
day = "1",
doi = "10.1002/jcp.10196",
language = "English",
volume = "194",
pages = "101--107",
journal = "Journal of cellular and comparative physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Cyclin T

T2 - Three forms for different roles in physiological and pathological functions

AU - De Luca, Antonio

AU - De Falco, Maria

AU - Baldi, Alfonso

AU - Paggi, Marco G.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Cyclins are members of family of proteins involved in the cell cycle regulation. They are regulatory subunits of complexes with proteins called cyclin-dependent kinases (CDKs). There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b. All cyclin T contain an N-terminal "cyclin homology box," the most conserved region among different members of the cyclin family that serves to bind CDK9. In addition to the N-terminal cyclin domain, cyclin T contains a putative coiled-coil motif, a His-rich motif, and a C-terminal PEST sequence. The CDK9/cyclin T complex is able to activate gene expression in a catalytic-dependent manner, phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. In addition, only cyclin T1 supports interactions between Tat and TAR. The interaction of Tat with cyclin T1 alters the conformation of Tat to enhance the affinity and specificity of the Tat:TAR interaction. On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells.

AB - Cyclins are members of family of proteins involved in the cell cycle regulation. They are regulatory subunits of complexes with proteins called cyclin-dependent kinases (CDKs). There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b. All cyclin T contain an N-terminal "cyclin homology box," the most conserved region among different members of the cyclin family that serves to bind CDK9. In addition to the N-terminal cyclin domain, cyclin T contains a putative coiled-coil motif, a His-rich motif, and a C-terminal PEST sequence. The CDK9/cyclin T complex is able to activate gene expression in a catalytic-dependent manner, phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. In addition, only cyclin T1 supports interactions between Tat and TAR. The interaction of Tat with cyclin T1 alters the conformation of Tat to enhance the affinity and specificity of the Tat:TAR interaction. On the other hand, CDK9/cyclin T2 complexes are involved in the regulation of terminal differentiation in muscle cells.

UR - http://www.scopus.com/inward/record.url?scp=0037294769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037294769&partnerID=8YFLogxK

U2 - 10.1002/jcp.10196

DO - 10.1002/jcp.10196

M3 - Article

C2 - 12494448

AN - SCOPUS:0037294769

VL - 194

SP - 101

EP - 107

JO - Journal of cellular and comparative physiology

JF - Journal of cellular and comparative physiology

SN - 0021-9541

IS - 2

ER -