Cyclo-oxygenase-1 and cyclo-oxygenase-2 and cardiovascular system

M. Lettino, F. Cantú, M. Mariani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Prostaglandins play important roles in the pathophysiological mechanism of action of platelets and endothelial cells in the cardiovascular system. The two isoforms of cyclo-oxygenase, respectively cyclo-oxygenase-1 and cyclo-oxygenase-2, are differently expressed in these cells. Activated platelets show a relatively large amount of cyclo-oxygenase-1, whereas endothelial cells have the gene for cyclo-oxygenase-2, the expression of which follows cell activation. In the atherosclerosis lesion, prostaglandin synthesis is mainly mediated by the inducible cyclo-oxygenase-2 expressed in macrophages/foam cells, smooth muscle cells and endothelial cells. Aspirin, a selective platelet cyclo-oxygenase-1 inhibitor, still remains the most extensively studied antiplatelet agent, even though there is growing evidence that many other compounds could be valuable either in association, or alternatives in antithrombotic therapy.

Original languageEnglish
JournalDigestive and Liver Disease
Volume33
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2001

Fingerprint

Prostaglandin-Endoperoxide Synthases
Cardiovascular System
Blood Platelets
Endothelial Cells
Prostaglandins
Foam Cells
Cyclooxygenase Inhibitors
Platelet Aggregation Inhibitors
Aspirin
Smooth Muscle Myocytes
Atherosclerosis
Protein Isoforms
Macrophages
Genes

Keywords

  • Aspirin
  • Atherosclerosis
  • Cyclo-oxygenase
  • Endothelial cells
  • Platelets
  • Prostaglandin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cyclo-oxygenase-1 and cyclo-oxygenase-2 and cardiovascular system. / Lettino, M.; Cantú, F.; Mariani, M.

In: Digestive and Liver Disease, Vol. 33, No. SUPPL. 2, 2001.

Research output: Contribution to journalArticle

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