Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy

Maurizio Viale, Rita Tosto, Valentina Giglio, Giuseppe Pappalardo, Valentina Oliveri, Irena Maric, Maria Addolorata Mariggiò, Graziella Vecchio

Research output: Contribution to journalArticle

Abstract

Polymeric cyclodextrin–based nanoparticles are currently undergoing clinical trials as nanotherapeutics. Using a non-covalent approach, we decorated two cross-linked cyclodextrin polymers of different molecular weights with an RGD peptide derivative to construct a novel carrier for the targeted delivery of doxorubicin. RGD is the binding sequence for the integrin receptor family that is highly expressed in tumour tissues. The assembled host–guest systems were investigated using NMR and DLS techniques. We found that, in comparison with free doxorubicin or the binary complex doxorubicin/cyclodextrin polymer, the RGD units decorating the cyclodextrin-based nanosystems improved the selectivity and cytotoxicity of the complexed doxorubicin towards cultured human tumour cell lines. Our results suggest that the nanocarriers under study may contribute to the development of new platforms for cancer therapy.

Original languageEnglish
JournalInvestigational New Drugs
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Cancer
  • Carbohydrates
  • Doxorubicin
  • Nanoparticles
  • Peptides

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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    Viale, M., Tosto, R., Giglio, V., Pappalardo, G., Oliveri, V., Maric, I., Mariggiò, M. A., & Vecchio, G. (Accepted/In press). Cyclodextrin polymers decorated with RGD peptide as delivery systems for targeted anti-cancer chemotherapy. Investigational New Drugs. https://doi.org/10.1007/s10637-018-0711-9