Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas

Carmela Pisano, Alessandro Ottaiano, Fabiana Tatangelo, Maurizio Di Bonito, Marzia Falanga, Vincenzo Rosario Iaffaioli, Gerardo Botti, Sandro Pignata, Angela Maria Acquaviva

Research output: Contribution to journalArticle

Abstract

Background: Cyclooxygenase-2 (COX-2) has been implicated in colorectal carcinogenesis but its role is not completely defined. Materials and Methods: The expression of COX-2 was evaluated in 68 paraffin-embedded sporadic colorectal adenomas by immunohistochemistry. Associations between COX-2 expression and the clinicopathological characteristics of the adenomas were studied by contingency tables and the Chi-square test. Results: Cytoplasmic staining for COX-2 protein was present in epithelial cells of 62 out of the 68 adenomas. COX-2 expression was not associated with age or gender. Furthermore, no significant correlations were found between the expression of the protein and histology (tubular vs tubulovillous), localization (proximal vs distal) or morphology (sessil vs pedunculated) of the adenomas. Both stromal and epithelial COX-2 expressions were higher in larger (>4 mm) compared with smaller (

Original languageEnglish
Pages (from-to)2065-2068
Number of pages4
JournalAnticancer Research
Volume25
Issue number3 B
Publication statusPublished - May 2005

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Keywords

  • Colorectal adenomas
  • Colorectal cancer
  • Cyclooxygenase-2

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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