Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy

Gaia Fumagalli, Davide Mazza, Michael S. Christodoulou, Giovanna Damia, Francesca Ricci, Dario Perdicchia, Barbara Stella, Franco Dosio, Panagiota A. Sotiropoulou, Daniele Passarella

Research output: Contribution to journalArticle

Abstract

Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).

Original languageEnglish
Pages (from-to)1380-1383
Number of pages4
JournalChemPlusChem
Volume80
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • cancer stem cells
  • cyclopamine
  • nanoparticles
  • paclitaxel

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Fumagalli, G., Mazza, D., Christodoulou, M. S., Damia, G., Ricci, F., Perdicchia, D., Stella, B., Dosio, F., Sotiropoulou, P. A., & Passarella, D. (2015). Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy. ChemPlusChem, 80(9), 1380-1383. https://doi.org/10.1002/cplu.201500156