Cyclophosphamide in the therapy of multiple sclerosis: A longitudinal study on intrathecal immunoglobulin response

E. Millefiorini; M. D. Giovanni; S. Bernardi; M. G. Grasso; M. Salvetti; F. Nuccetelli; D. Gambi

Cyclophosphamide in the therapy of multiple sclerosis: A longitudinal study on intrathecal immunoglobulin response

E. Millefiorini, M. D. Giovanni, S. Bernardi, M. G. Grasso, M. Salvetti, F. Nuccetelli, D. Gambi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Eleven patients with chronic-progressive Multiple Sclerosis were treated with 700 gr/m² of cyclophosphamide (CTX) intravenously for five days and a single dose was repeated every two months for 12 months. All patients were submitted to a lumbar puncture before therapy, one month and six months after the beginning of the treatment in order to analyze the behaviour of liquoral IgG in our therapeutic schedule with CTX. The liquoral IgG resulted elevated in all patients at the basal sampling. In the second lumbar puncture the IgG were significantly decreased while a trend towards increased levels was again observed after six months from the treatment.

Original language	English
Pages (from-to)	59-62
Number of pages	4
Journal	International Journal of Immunopathology and Pharmacology
Volume	3
Issue number	1
Publication status	Published - 1990

ASJC Scopus subject areas

Pharmacology

Cite this

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abstract = "Eleven patients with chronic-progressive Multiple Sclerosis were treated with 700 gr/m2 of cyclophosphamide (CTX) intravenously for five days and a single dose was repeated every two months for 12 months. All patients were submitted to a lumbar puncture before therapy, one month and six months after the beginning of the treatment in order to analyze the behaviour of liquoral IgG in our therapeutic schedule with CTX. The liquoral IgG resulted elevated in all patients at the basal sampling. In the second lumbar puncture the IgG were significantly decreased while a trend towards increased levels was again observed after six months from the treatment.",

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year = "1990",

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T1 - Cyclophosphamide in the therapy of multiple sclerosis

T2 - A longitudinal study on intrathecal immunoglobulin response

AU - Millefiorini, E.

AU - Giovanni, M. D.

AU - Bernardi, S.

AU - Grasso, M. G.

AU - Salvetti, M.

AU - Nuccetelli, F.

AU - Gambi, D.

PY - 1990

Y1 - 1990

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AB - Eleven patients with chronic-progressive Multiple Sclerosis were treated with 700 gr/m2 of cyclophosphamide (CTX) intravenously for five days and a single dose was repeated every two months for 12 months. All patients were submitted to a lumbar puncture before therapy, one month and six months after the beginning of the treatment in order to analyze the behaviour of liquoral IgG in our therapeutic schedule with CTX. The liquoral IgG resulted elevated in all patients at the basal sampling. In the second lumbar puncture the IgG were significantly decreased while a trend towards increased levels was again observed after six months from the treatment.

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Cyclophosphamide in the therapy of multiple sclerosis: A longitudinal study on intrathecal immunoglobulin response

Abstract

ASJC Scopus subject areas

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