Cyclophosphamide, methotrexate, 5-fluorouracil (CMF) in advanced gastrointestinal cancer

A. Scanni, M. Tomirotti, A. Margulis, M. Biraghi, G. Curtarelli

Research output: Contribution to journalArticlepeer-review


The effectiveness of the cyclophosphamide + methotrexate + 5-fluorouracil schedule (CMF) in 28 patients with advanced gastrointestinal cancer has been studied. No complete remission was obtained; partial remission and objective improvement constituted 56%. The median response period is calculated at a minimum of 12 months, without significant differences between the group of patients previously subjected to palliative canalization surgery and the group of patients not subjected to this operation. The overall median survival time is 10.8 months. On the basis of the data given, the authors conclude by stressing that the CMF combination should be studied more fully in relation to its use in gastrointestinal forms of cancer.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research


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