Cyclophosphates V in vivo metabolic and cardiovascular effects of new cyclophosphates

R. Paoletti, F. Berti, P. F. Spano, G. Michal, G. Weimann, M. Nelboeck

Research output: Contribution to journalArticlepeer-review


New synthetic derivatives of natural cyclic nucleotides have been tested for their metabolic (blood glucose and plasma corticosterone) and cardiovascular (heart rate and blood pressure) effects in the rat. A clear cut specificity of the effects emerges from the comparison between the different series of substituted nucleotides (N6, 2′O-8-and 2-substitutions). A long lasting effect on plasma steroid levels has been demonstrated with the compound 6-(3′4′-dimethoxyphenyl-)ethyl-amino-3′,5′-PuMP+, at doses and times where there is no effect on the cardiovascular parameters or blood glucose levels.

Original languageEnglish
Pages (from-to)87-100
Number of pages14
JournalPharmacological Research Communications
Issue number1
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Pharmacology


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