Cyclosporin A and islet function

Giacomo Basadonna; Francesco Montorsi; Kenji Kakizaki; Ronald C. Merrell

doi:10.1016/S0002-9610(88)80064-3

Cyclosporin A and islet function

Giacomo Basadonna, Francesco Montorsi, Kenji Kakizaki, Ronald C. Merrell

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Long-term cyclosporin A (CsA) administration in dogs was studied with respect to function of the islets of Langerhans. After 3 weeks of immunosuppression with therapeutic doses, the islets were isolated and assessed in vitro for insulin release in response to glucose challenge. Islet tissue retrieved from the CsA-treated animals showed a total insulin output significantly lower than that of the control animals (p

Original language	English
Pages (from-to)	191-193
Number of pages	3
Journal	American Journal of Surgery
Volume	156
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9610(88)80064-3
Publication status	Published - 1988

ASJC Scopus subject areas

Surgery

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10.1016/S0002-9610(88)80064-3

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title = "Cyclosporin A and islet function",

abstract = "Long-term cyclosporin A (CsA) administration in dogs was studied with respect to function of the islets of Langerhans. After 3 weeks of immunosuppression with therapeutic doses, the islets were isolated and assessed in vitro for insulin release in response to glucose challenge. Islet tissue retrieved from the CsA-treated animals showed a total insulin output significantly lower than that of the control animals (p",

author = "Giacomo Basadonna and Francesco Montorsi and Kenji Kakizaki and Merrell, {Ronald C.}",

year = "1988",

doi = "10.1016/S0002-9610(88)80064-3",

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T1 - Cyclosporin A and islet function

AU - Basadonna, Giacomo

AU - Montorsi, Francesco

AU - Kakizaki, Kenji

AU - Merrell, Ronald C.

PY - 1988

Y1 - 1988

N2 - Long-term cyclosporin A (CsA) administration in dogs was studied with respect to function of the islets of Langerhans. After 3 weeks of immunosuppression with therapeutic doses, the islets were isolated and assessed in vitro for insulin release in response to glucose challenge. Islet tissue retrieved from the CsA-treated animals showed a total insulin output significantly lower than that of the control animals (p

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Cyclosporin A and islet function

Abstract

ASJC Scopus subject areas

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