Cyclosporin A and islet function

Giacomo Basadonna, Francesco Montorsi, Kenji Kakizaki, Ronald C. Merrell

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term cyclosporin A (CsA) administration in dogs was studied with respect to function of the islets of Langerhans. After 3 weeks of immunosuppression with therapeutic doses, the islets were isolated and assessed in vitro for insulin release in response to glucose challenge. Islet tissue retrieved from the CsA-treated animals showed a total insulin output significantly lower than that of the control animals (p

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalAmerican Journal of Surgery
Volume156
Issue number3
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery

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