Abstract
HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also well demonstrated that HAART alone is not able to eradicate the virus, unless over a life-long period of time. There is therefore the need to develop alternative strategies aimed at modulating the immune responses in order to achieve the long-term control of HIV even once HAART is discontinued. Among immunomodulant agents, cyclosporin A in combination with HAART might play a role in the treatment of people with primary HIV-1 infection.
| Original language | English |
|---|---|
| Pages (from-to) | 79-81 |
| Number of pages | 3 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 2000 |
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Keywords
- Cyclosporin A
- HAART
- HIV eradication
- Immune-based strategies
- Immunosuppression
- Primary HIV-1 infection
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Physiology (medical)
- Medicine (miscellaneous)
- Physiology
- Agricultural and Biological Sciences(all)
Cite this
Cyclosporin A in combination with HAART in primary HIV-1 infection. / Rizzardi, G. P.; Vaccarezza, M.; Capiluppi, B.; Tambussi, G.; Lazzarin, A.; Pantaleo, G.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 14, No. 1, 2000, p. 79-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cyclosporin A in combination with HAART in primary HIV-1 infection
AU - Rizzardi, G. P.
AU - Vaccarezza, M.
AU - Capiluppi, B.
AU - Tambussi, G.
AU - Lazzarin, A.
AU - Pantaleo, G.
PY - 2000
Y1 - 2000
N2 - HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also well demonstrated that HAART alone is not able to eradicate the virus, unless over a life-long period of time. There is therefore the need to develop alternative strategies aimed at modulating the immune responses in order to achieve the long-term control of HIV even once HAART is discontinued. Among immunomodulant agents, cyclosporin A in combination with HAART might play a role in the treatment of people with primary HIV-1 infection.
AB - HAART is the cornerstone of HIV therapy, and has significantly reduced morbidity and mortality associated with HIV disease. The institution of HAART during the primary HIV-1 infection has a more profound influence on the ultimate pattern and rate of disease progression than therapy commenced later on. However, it also well demonstrated that HAART alone is not able to eradicate the virus, unless over a life-long period of time. There is therefore the need to develop alternative strategies aimed at modulating the immune responses in order to achieve the long-term control of HIV even once HAART is discontinued. Among immunomodulant agents, cyclosporin A in combination with HAART might play a role in the treatment of people with primary HIV-1 infection.
KW - Cyclosporin A
KW - HAART
KW - HIV eradication
KW - Immune-based strategies
KW - Immunosuppression
KW - Primary HIV-1 infection
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UR - http://www.scopus.com/inward/citedby.url?scp=0034457544&partnerID=8YFLogxK
M3 - Article
C2 - 10763900
AN - SCOPUS:0034457544
VL - 14
SP - 79
EP - 81
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 1
ER -