Cyclosporin a serum and blood levels in marrow graft recipients: Correlation with administered dose, serum creatinine and graft-versus-host disease

A. Bacigalupo, Di Giorgio, F. Frassoni, M. T. VanLint, M. R. Raffo, L. Gogioso, M. Viale, A. M. Marmont

Research output: Contribution to journalArticlepeer-review

Abstract

23 patients undergoing marrow transplantation for leukemia or aplastic anemia were given cyclosporin A (CyA) for graft-versus-host disease (GvHD) prophylaxis. A radioimmunoassay was used to monitor CyA serum levels in 13 patients and whole blood levels in 10. Serum creatinine levels were recorded daily until day 30 and then weekly. The severity of acute GvHD was recorded daily for a total of 1,738 patient days. CyA dose was then correlated with CyA serum or blood levels, serum creatinine levels and severity of acute GvHD.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalActa Haematologica
Volume72
Issue number3
Publication statusPublished - 1984

Keywords

  • Bone marrow transplant
  • Cyclosporin A

ASJC Scopus subject areas

  • Hematology

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