Cyclosporin A specifically affects nuclear PLCβ1 in immunodepressed heart transplant patients with gingival overgrowth

A. Ruggeri, L. Montebugnoli, A. Matteucci, N. Zini, L. Solimando, D. Servidio, P. Suppa, M. Cadenaro, L. Cocco, L. Breschi

Research output: Contribution to journalArticlepeer-review


One of the most commonly observed adverse effects of cyclosporin A (CsA) is the development of gingival overgrowth (GO). Fibroblasts are involved in GO, but the question why only a percentage of patients undergoing CsA treatment shows this side-effect remains unanswered. In a previous study, CsA has been demonstrated to induce over-expression of phospholipase C (PLC) β1 in fibroblasts of patients with clinical GO, in cells from both enlarged and clinically healthy gingival sites. In this work, we assessed the expression of PLCβ isoforms to investigate whether the exaggerated fibroblast response to CsA related to increased PLCβ1 expression could also be detected in CsA-treated patients without clinical signs of GO. Our results support the hypothesis of a multi-factorial origin of gingival overgrowth, including specific changes within the gingival tissues orchestrating fibroblastic hyperresponsiveness as a consequence of a long-term in vivo exposure to cyclosporin A.

Original languageEnglish
Pages (from-to)747-751
Number of pages5
JournalJournal of Dental Research
Issue number8
Publication statusPublished - Aug 2005


  • Cyclosporin A
  • Gingival overgrowth
  • Immuno-TEM
  • Immunoblotting
  • Phospholipase C

ASJC Scopus subject areas

  • Dentistry(all)

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