Cyclosporine A inhibits polymorphonuclear leukocyte chemotaxis in vivo

P. D. Pigatto, N. Mozzanica, M. M. Polenghi, G. F. Altomare, A. F. Finzi

Research output: Contribution to journalArticle

Abstract

We have examined the effects of CsA therapy on the ability of serum and neutrophils from psoriatics to stimulate chemotaxis. No statistically significant changes were detected. The discrepancy between the in vivo and the in vitro findings cannot be explained at the moment with this small sample of patients. The depression of neutrophil function observed in vivo during treatment could be a cause or a consequence of the clearing of the psoriasis. The results clearly indicate that CsA can inhibit in vivo migration of neutrophils out of the dermal capillaries. It seems likely that this is an inflammatory effect and not a modification of neutrophil function. This antiinflammatory activity may be one of the mechanisms by which CsA therapy improves psoriasis.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalTransplantation Proceedings
Volume20
Issue number3 SUPPL. 4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Pigatto, P. D., Mozzanica, N., Polenghi, M. M., Altomare, G. F., & Finzi, A. F. (1988). Cyclosporine A inhibits polymorphonuclear leukocyte chemotaxis in vivo. Transplantation Proceedings, 20(3 SUPPL. 4), 91-94.