Abstract
Cyclosporine A (CsA) is the most commonly used drug in organ transplantation. To evaluate exposure the gold standard is area under curve (AUC), but this is expensive and requires many blood samples. For this reason, abbreviated formulae have been developed in adults. Data in children are scanty. Formulae cannot be applied in patients taking CsA every 8 h. We tested the abbreviated AUC formula published for adults in renal transplant children on twice daily therapy and we propose a method, requiring three blood samples, for those taking CsA every 8 h. A very good correlation was obtained for both groups. Furthermore, we studied the correlation between CsA concentration 2 h after administration and AUC. A good correlation was found supporting the possible use of this parameter for monitoring CsA therapy.
Original language | English |
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Pages (from-to) | 95-97 |
Number of pages | 3 |
Journal | Pediatric Nephrology |
Volume | 13 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1999 |
Keywords
- Abbreviated formulae
- Area under curve
- C2 concentration
- Cyclosporine monitoring
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health