Fifty-eight type I diabetic patients experienced end-stage renal failure, and received double simultaneous pancreas plus kidney transplantation. Three different immunosuppressive protocols were used: Conventional therapy (azathioprine, steroids, and ALG; group A, 23 patients), CsA from the beginning (group B, seven patients), and CsA after an early period of conventional therapy (group C, 24 patients). The long-term survival rates of patients and both transplanted organs were improved in groups A and B. No difference in the rate of early graft failure was observed in the three protocols. CsA might ameliorate the metabolic control in comparison with steroid therapy (OGTT and 24-hour metabolic profile).
|Number of pages||4|
|Issue number||1 I|
|Publication status||Published - 1985|
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