Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients

Research output: Contribution to journalArticle

Abstract

We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalPediatric Nephrology
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 1996

Keywords

  • Acute hemodynamic effect
  • Cyclosporine
  • Renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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