Cyclosporine metabolism and pharmacokinetics following intravenous and oral administration in the dog

Bruno Gridelli, Lenia Scanlon, Riccardo Pellicci, Real Lapointe, Andre Dewolf, Howard Seltman, Warren Diven, Byers Shaw, Thomas Starzl, Ajit Sanghvi

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of assay method on single dose cyclosporine (CsA) pharmacokinetics was studied in nine dogs receiving either i.v. or oral CsA. Samples were drawn from hepatic, portal, and systemic veins at various times after the dose and CsA levels were determined by radiommunoassay (RIA) and high-performance liquid chromatography (HPLC). Blood concentration-time data were analyzed by nonlinear least-squares regression, using two-compartment models. RIA/HPLC ratios for all samples were greater than one, and did not change significantly over time. The mean RIA/HPLC ratios for samples drawn from all three veins were higher after oral than i.v. doses of the drug (T="I">P

Original languageEnglish
Pages (from-to)388-391
Number of pages4
JournalTransplantation
Volume41
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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