Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Claudio Pulito, Federica Mori, Andrea Sacconi, Luca Casadei, Maria Ferraiuolo, Maria Cristina Valerio, Raffaela Santoro, Frauke Goeman, Anna Maidecchi, Luisa Mattoli, Cesare Manetti, Silvia Di Agostino, Paola Muti, Giovanni Blandino, Sabrina Strano

Research output: Contribution to journalArticle

Abstract

Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.

Original languageEnglish
Pages (from-to)18134-18150
Number of pages17
JournalOncotarget
Volume6
Issue number20
Publication statusPublished - 2015

Keywords

  • Apoptosis
  • Invasion
  • Mesothelioma
  • Pathway
  • Tumorigenicity

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Pulito, C., Mori, F., Sacconi, A., Casadei, L., Ferraiuolo, M., Valerio, M. C., Santoro, R., Goeman, F., Maidecchi, A., Mattoli, L., Manetti, C., Di Agostino, S., Muti, P., Blandino, G., & Strano, S. (2015). Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion. Oncotarget, 6(20), 18134-18150.