Cystatin C and contrast-induced acute kidney injury

Carlo Briguori, Gabriella Visconti, Natalia V. Rivera, Amelia Focaccio, Bruno Golia, Rosalia Giannone, Diletta Castaldo, Francesca De Micco, Bruno Ricciardelli, Antonio Colombo

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

BACKGROUND-: Cystatin C (CyC) is more sensitive than serum creatinine (sCr) to rapidly detect acute changes in renal function. METHODS AND RESULTS-: We measured CyC together with sCr in 410 consecutive patients with chronic kidney disease undergoing either coronary and/or peripheral angiography and/or angioplasty. sCr was assessed at baseline and 24 and 48 hours after contrast media exposure. CyC was assessed at baseline and at 24 hours. Major adverse events (including death of any cause and dialysis) at 12 months were assessed. At 48 hours after contrast media exposure, contrast-induced acute kidney injury (defined as a sCr increase >0.3 mg/dL) occurred in 34 patients (8.2%). A CyC increase concentration >10% at 24 hours after contrast media exposure was detected in 87 patients (21.2%). This was the best CyC cutoff for the early identification of patients at risk for contrast-induced acute kidney injury (negative predictive value=100%; positive predictive value=39.1%). According to the defined cutoffs (that is, increase in CyC >0% and sCr >0.3 mg/dL), major adverse events occurred in 16 of 297 patients (5.4%) without any cutoffs satisfied (group 1), in 9 of 49 patients (18.4%) with only a CyC increase >10% (group 2), and in 9 of 31 patients (29%) with both cutoffs satisfied (group 3). By logistic regression analysis, the independent predictors of major adverse events at 1 year were group 2 (odds ratio=2.52; 95% confidence interval, 1.17 to 5.41; P=0.02), group 3 (odds ratio=4.45; 95% confidence interval, 1.72 to 11.54; P=0.002), and baseline glomerular filtration rate (odds ratio=0.91; 95% confidence interval, 0.88 to 0.95; P

Original languageEnglish
Pages (from-to)2117-2122
Number of pages6
JournalCirculation
Volume121
Issue number19
DOIs
Publication statusPublished - May 18 2010

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Cystatin C
Acute Kidney Injury
Creatinine
Contrast Media
Serum
Odds Ratio
Confidence Intervals
Glomerular Filtration Rate
Chronic Renal Insufficiency
Angioplasty
Dialysis
Cause of Death
Angiography
Logistic Models
Regression Analysis
Kidney

Keywords

  • Contrast media
  • Kidney
  • Prognosis

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Briguori, C., Visconti, G., Rivera, N. V., Focaccio, A., Golia, B., Giannone, R., ... Colombo, A. (2010). Cystatin C and contrast-induced acute kidney injury. Circulation, 121(19), 2117-2122. https://doi.org/10.1161/CIRCULATIONAHA.109.919639

Cystatin C and contrast-induced acute kidney injury. / Briguori, Carlo; Visconti, Gabriella; Rivera, Natalia V.; Focaccio, Amelia; Golia, Bruno; Giannone, Rosalia; Castaldo, Diletta; De Micco, Francesca; Ricciardelli, Bruno; Colombo, Antonio.

In: Circulation, Vol. 121, No. 19, 18.05.2010, p. 2117-2122.

Research output: Contribution to journalArticle

Briguori, C, Visconti, G, Rivera, NV, Focaccio, A, Golia, B, Giannone, R, Castaldo, D, De Micco, F, Ricciardelli, B & Colombo, A 2010, 'Cystatin C and contrast-induced acute kidney injury', Circulation, vol. 121, no. 19, pp. 2117-2122. https://doi.org/10.1161/CIRCULATIONAHA.109.919639
Briguori C, Visconti G, Rivera NV, Focaccio A, Golia B, Giannone R et al. Cystatin C and contrast-induced acute kidney injury. Circulation. 2010 May 18;121(19):2117-2122. https://doi.org/10.1161/CIRCULATIONAHA.109.919639
Briguori, Carlo ; Visconti, Gabriella ; Rivera, Natalia V. ; Focaccio, Amelia ; Golia, Bruno ; Giannone, Rosalia ; Castaldo, Diletta ; De Micco, Francesca ; Ricciardelli, Bruno ; Colombo, Antonio. / Cystatin C and contrast-induced acute kidney injury. In: Circulation. 2010 ; Vol. 121, No. 19. pp. 2117-2122.
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AU - Castaldo, Diletta

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