Cystatin C and risk of mortality among patients undergoing percutaneous coronary intervention

Fabio Angeli, Paolo Verdecchia, Stefano Savonitto, Gustavo Arraiz, Martina Zaninotto, Andrea Broccatelli, Chiara Cosma, Stefano D. Servi, Federico Sabino, Carlo Briguori, Giuseppe Ambrosio, Claudio Cavallini

Research output: Contribution to journalArticle

Abstract

Aims: We tested the prognostic value of cystatin C in patients with documented coronary artery disease (CAD) who underwent percutaneous coronary artery intervention (PCI). We also tested the hypothesis that the incremental predictive value of cystatin C on all-cause mortality was superior to that of glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) formula. Methods and results: Included in the study were 2,757 patients (mean age 63 years, 77% men). Blood samples for cystatin C levels were collected immediately before PCI. During a median follow-up of two years, 114 patients died. In multivariable Cox analyses, after adjustment for several confounders, GFR (p=0.004) and cystatin C concentration (p

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalEuroIntervention
Volume11
Issue number7
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Coronary artery disease
  • Cystatin C
  • Estimated glomerular filtration rate
  • Percutaneous transluminal coronary intervention
  • Prognosis
  • Receiver-operating characteristic curve analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Angeli, F., Verdecchia, P., Savonitto, S., Arraiz, G., Zaninotto, M., Broccatelli, A., Cosma, C., Servi, S. D., Sabino, F., Briguori, C., Ambrosio, G., & Cavallini, C. (2015). Cystatin C and risk of mortality among patients undergoing percutaneous coronary intervention. EuroIntervention, 11(7), 757-764. https://doi.org/10.4244/EIJY14M08-02