Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate

Giampaolo Niccoli, Micaela Conte, Roberta Della Bona, Luca Altamura, Massimo Siviglia, Ilaria Dato, Giuseppe Ferrante, Antonio M. Leone, Italo Porto, Francesco Burzotta, Salvatore Brugaletta, Luigi M. Biasucci, Filippo Crea

Research output: Contribution to journalArticle

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Abstract

Objective: Cystatin C (Cys-C) is an accurate marker of renal function. Recent studies have shown that serum Cys-C levels predict the risk of cardiovascular events. The causes of this association, however, are largely unknown. Methods and results: Seventy consecutive patients (age 62 ± 12, male sex 87%) undergoing coronary angiography because of typical chest pain and found to have coronary artery disease were included in the present study. Patients with abnormal creatinine-derived glomerular filtration rate (2) were excluded in order to avoid the well-known effect of overt renal insufficiency on coronary atherosclerosis. Coronary angiography was evaluated by two expert angiographers who assessed disease severity and extent according to the Sullivan's score and lesion morphology. In all patients, Cys-C and C-Reactive Protein (CRP) serum levels were measured on admission. Multivariable analysis was performed to assess independent predictors of angiographic measures. Diabetes was the only predictor of disease severity (p = 0.005), while male sex (p = 0.03), hypercholesterolemia (p = 0.04), diabetes (p <0.0001) and Cys-C (p <0.0001) were independent predictors of disease extent. Independent predictors of smooth lesions were diabetes (p <0.001) and Cys-C (p = 0.005). No correlation was found between Cys-C and CRP serum levels (p = 0.6). Conclusion: Cys-C is associated with coronary atherosclerosis extent and a smooth lesion morphology. The long-term prognostic role of Cys-C might be accounted for by a greater atherosclerotic burden, a necessary substrate for plaque destabilization.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalAtherosclerosis
Volume198
Issue number2
DOIs
Publication statusPublished - Jun 2008

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Cystatin C
Glomerular Filtration Rate
Myocardial Ischemia
Phenotype
Coronary Artery Disease
Coronary Angiography
C-Reactive Protein
Serum
Hypercholesterolemia
Chest Pain
Renal Insufficiency
Creatinine
Kidney

Keywords

  • Atherosclerosis
  • Coronary angiography
  • Cystatin C

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate. / Niccoli, Giampaolo; Conte, Micaela; Bona, Roberta Della; Altamura, Luca; Siviglia, Massimo; Dato, Ilaria; Ferrante, Giuseppe; Leone, Antonio M.; Porto, Italo; Burzotta, Francesco; Brugaletta, Salvatore; Biasucci, Luigi M.; Crea, Filippo.

In: Atherosclerosis, Vol. 198, No. 2, 06.2008, p. 373-380.

Research output: Contribution to journalArticle

Niccoli, G, Conte, M, Bona, RD, Altamura, L, Siviglia, M, Dato, I, Ferrante, G, Leone, AM, Porto, I, Burzotta, F, Brugaletta, S, Biasucci, LM & Crea, F 2008, 'Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate', Atherosclerosis, vol. 198, no. 2, pp. 373-380. https://doi.org/10.1016/j.atherosclerosis.2007.09.022
Niccoli, Giampaolo ; Conte, Micaela ; Bona, Roberta Della ; Altamura, Luca ; Siviglia, Massimo ; Dato, Ilaria ; Ferrante, Giuseppe ; Leone, Antonio M. ; Porto, Italo ; Burzotta, Francesco ; Brugaletta, Salvatore ; Biasucci, Luigi M. ; Crea, Filippo. / Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate. In: Atherosclerosis. 2008 ; Vol. 198, No. 2. pp. 373-380.
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abstract = "Objective: Cystatin C (Cys-C) is an accurate marker of renal function. Recent studies have shown that serum Cys-C levels predict the risk of cardiovascular events. The causes of this association, however, are largely unknown. Methods and results: Seventy consecutive patients (age 62 ± 12, male sex 87{\%}) undergoing coronary angiography because of typical chest pain and found to have coronary artery disease were included in the present study. Patients with abnormal creatinine-derived glomerular filtration rate (2) were excluded in order to avoid the well-known effect of overt renal insufficiency on coronary atherosclerosis. Coronary angiography was evaluated by two expert angiographers who assessed disease severity and extent according to the Sullivan's score and lesion morphology. In all patients, Cys-C and C-Reactive Protein (CRP) serum levels were measured on admission. Multivariable analysis was performed to assess independent predictors of angiographic measures. Diabetes was the only predictor of disease severity (p = 0.005), while male sex (p = 0.03), hypercholesterolemia (p = 0.04), diabetes (p <0.0001) and Cys-C (p <0.0001) were independent predictors of disease extent. Independent predictors of smooth lesions were diabetes (p <0.001) and Cys-C (p = 0.005). No correlation was found between Cys-C and CRP serum levels (p = 0.6). Conclusion: Cys-C is associated with coronary atherosclerosis extent and a smooth lesion morphology. The long-term prognostic role of Cys-C might be accounted for by a greater atherosclerotic burden, a necessary substrate for plaque destabilization.",
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T1 - Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate

AU - Niccoli, Giampaolo

AU - Conte, Micaela

AU - Bona, Roberta Della

AU - Altamura, Luca

AU - Siviglia, Massimo

AU - Dato, Ilaria

AU - Ferrante, Giuseppe

AU - Leone, Antonio M.

AU - Porto, Italo

AU - Burzotta, Francesco

AU - Brugaletta, Salvatore

AU - Biasucci, Luigi M.

AU - Crea, Filippo

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N2 - Objective: Cystatin C (Cys-C) is an accurate marker of renal function. Recent studies have shown that serum Cys-C levels predict the risk of cardiovascular events. The causes of this association, however, are largely unknown. Methods and results: Seventy consecutive patients (age 62 ± 12, male sex 87%) undergoing coronary angiography because of typical chest pain and found to have coronary artery disease were included in the present study. Patients with abnormal creatinine-derived glomerular filtration rate (2) were excluded in order to avoid the well-known effect of overt renal insufficiency on coronary atherosclerosis. Coronary angiography was evaluated by two expert angiographers who assessed disease severity and extent according to the Sullivan's score and lesion morphology. In all patients, Cys-C and C-Reactive Protein (CRP) serum levels were measured on admission. Multivariable analysis was performed to assess independent predictors of angiographic measures. Diabetes was the only predictor of disease severity (p = 0.005), while male sex (p = 0.03), hypercholesterolemia (p = 0.04), diabetes (p <0.0001) and Cys-C (p <0.0001) were independent predictors of disease extent. Independent predictors of smooth lesions were diabetes (p <0.001) and Cys-C (p = 0.005). No correlation was found between Cys-C and CRP serum levels (p = 0.6). Conclusion: Cys-C is associated with coronary atherosclerosis extent and a smooth lesion morphology. The long-term prognostic role of Cys-C might be accounted for by a greater atherosclerotic burden, a necessary substrate for plaque destabilization.

AB - Objective: Cystatin C (Cys-C) is an accurate marker of renal function. Recent studies have shown that serum Cys-C levels predict the risk of cardiovascular events. The causes of this association, however, are largely unknown. Methods and results: Seventy consecutive patients (age 62 ± 12, male sex 87%) undergoing coronary angiography because of typical chest pain and found to have coronary artery disease were included in the present study. Patients with abnormal creatinine-derived glomerular filtration rate (2) were excluded in order to avoid the well-known effect of overt renal insufficiency on coronary atherosclerosis. Coronary angiography was evaluated by two expert angiographers who assessed disease severity and extent according to the Sullivan's score and lesion morphology. In all patients, Cys-C and C-Reactive Protein (CRP) serum levels were measured on admission. Multivariable analysis was performed to assess independent predictors of angiographic measures. Diabetes was the only predictor of disease severity (p = 0.005), while male sex (p = 0.03), hypercholesterolemia (p = 0.04), diabetes (p <0.0001) and Cys-C (p <0.0001) were independent predictors of disease extent. Independent predictors of smooth lesions were diabetes (p <0.001) and Cys-C (p = 0.005). No correlation was found between Cys-C and CRP serum levels (p = 0.6). Conclusion: Cys-C is associated with coronary atherosclerosis extent and a smooth lesion morphology. The long-term prognostic role of Cys-C might be accounted for by a greater atherosclerotic burden, a necessary substrate for plaque destabilization.

KW - Atherosclerosis

KW - Coronary angiography

KW - Cystatin C

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