Cystic fibrosis: A surgical matter?

Tamara Caldaro, Federico Alghisi, Paola De Angelis, Maria Carmen Garganese, Francesca Rea, Milena Pizzoferro, Maria Felicia Villani, Erminia Francesca Romeo, Filippo Torroni, Francesca Foschia, Rosa Alba Gambitta, Giovanni Federici, Vincenzina Lucidi, Luigi Dall'Oglio

Research output: Contribution to journalArticlepeer-review


Background Gastroesophageal reflux disease (GERD) is very common in patients with chronic lung diseases. We evaluated the incidence of GERD in young patients with cystic fibrosis (CF) and defined the characteristics of gastroesophageal reflux episodes analyzed by pH-multichannel intraluminal impedance (pH-MII) and esophagogastric scintigraphy. Patients and methods Since 2010, 31 patients with CF underwent pH-MII. Scintigraphy and upper endoscopy were performed in positive GERD patients. Forced expiratory volume in 1 second (FEV1%) predicted was detected. Results pH-MII was positive in 17/31 (54.8%) patients (mean age: 12.4 years; range: 4-17 years). pH monitoring detected an average of 64.6 acid reflux events 4.4 episodes > 5 minutes in duration. The DeMeester score was 38.5. Impedance identified a mean number of reflux episodes of 66 (65.2% acid; 32% weakly acidic; 2.8% nonacidic), 28% of which reached the proximal esophagus. Esophageal transit and gastric emptying were delayed in 6/13 (46.1%) and in 5/15 (33.3%) cases, respectively. No differences were found in lung function between positive and negative GERD patients (P = 0.88). Conclusions Pediatric patients with CF have a high incidence of GERD with acidic events. These patients should be investigated with pH-MII and scintigraphy in order to make an early diagnosis and determine the most appropriate follow-up.

Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalJournal of Pediatric Surgery
Issue number5
Publication statusPublished - 2014


  • Cystic fibrosis
  • Fundoplication
  • Gastric scintigraphy
  • GERD
  • pH-multichannel intraluminal impedance

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


Dive into the research topics of 'Cystic fibrosis: A surgical matter?'. Together they form a unique fingerprint.

Cite this