Cystic fibrosis and antibiotic hypersensitivity: Present knowledge and practical approach

D. Caimmi, R. Chiron, F. Tremblay, S. Caimmi, A. Ricci, A. Licari, Gl Marseglia

Research output: Contribution to journalArticle

Abstract

Cystic fibrosis is one of the most common fatal genetic diseases (1 in 2500 births). The defect causing the disease is localized on the 7q31 gene, which codifies for the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) transmembrane protein. CFTR is a chloride channel localized on the epithelial cells of the mucosa of the respiratory tract, pancreatic ducts, biliary tree, intestine, vas deferens, and sweat glands. More than 2000 different mutations are currently known; some are prominent or relatively frequent, ranging from one population to another. The most frequent complications of cystic fibrosis are those affecting the bronchial tree. Patients suffer from recurrent lung infections, which involve a progressive loss of lung function. The pulmonary infections are frequent or chronic and limit the quality of life of patients. In addition to being enormously exposed to antibiotics, they have many more opportunities to develop hypersensitivity reactions to these molecules. Only a complete allergy work-up with a detailed analysis of the clinical history, skin tests and provocation test can show if the patient has actually experienced an allergic hypersensitivity reaction. Desensitization is to be considered as a treatment that may help patients benefit from antibiotic treatment in those cases in which they have a proven allergy to a certain molecule.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalJournal of Biological Regulators and Homeostatic Agents
Volume29
Issue number2
Publication statusPublished - Apr 1 2015

Fingerprint

Cystic Fibrosis
Hypersensitivity
Anti-Bacterial Agents
Cystic Fibrosis Transmembrane Conductance Regulator
Lung
Sweat Glands
Inborn Genetic Diseases
Chloride Channels
Vas Deferens
Pancreatic Ducts
Biliary Tract
Infection
Skin Tests
Respiratory System
Intestines
Mucous Membrane
Epithelial Cells
Quality of Life
Parturition
Mutation

Keywords

  • Allergy work-up
  • Antibiotics
  • Cystic fibrosis
  • Desensitization
  • Drug allergy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cystic fibrosis and antibiotic hypersensitivity : Present knowledge and practical approach. / Caimmi, D.; Chiron, R.; Tremblay, F.; Caimmi, S.; Ricci, A.; Licari, A.; Marseglia, Gl.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 29, No. 2, 01.04.2015, p. 29-37.

Research output: Contribution to journalArticle

Caimmi, D, Chiron, R, Tremblay, F, Caimmi, S, Ricci, A, Licari, A & Marseglia, G 2015, 'Cystic fibrosis and antibiotic hypersensitivity: Present knowledge and practical approach', Journal of Biological Regulators and Homeostatic Agents, vol. 29, no. 2, pp. 29-37.
Caimmi, D. ; Chiron, R. ; Tremblay, F. ; Caimmi, S. ; Ricci, A. ; Licari, A. ; Marseglia, Gl. / Cystic fibrosis and antibiotic hypersensitivity : Present knowledge and practical approach. In: Journal of Biological Regulators and Homeostatic Agents. 2015 ; Vol. 29, No. 2. pp. 29-37.
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