Cytidine-5′-diphosphocholine (Citicoline): A pilot study in patients with non-arteritic ischaemic optic neuropathy

V. Parisi, G. Coppola, L. Ziccardi, G. Gallinaro, B. Falsini

Research output: Contribution to journalArticlepeer-review


Background and purpose: Our work evaluates visual function before and after treatment with cytidine-5-diphosphocholine (Citicoline) in patients with non-arteritic ischaemic optic neuropathy (NION). Methods: Twenty-six patients in which at least 6 months elapsed from NION, were randomly divided into two age-similar groups: 14 patients had Citicoline (Cebrolux-Tubilux, Italy, 1600 mg/diem for 60 days, followed by a 120-day period of wash out, days 60-180) (T-NION); 12 patients had no treatment during the same period (NT-NION). At day 180, in T-NION a second period of treatment (days 181-240) followed by a wash-out (days 241-360) was performed. Fourteen age-matched healthy subjects provided normative data. In all patients, pattern-electroretinogram (PERG), visual evoked potentials (VEPs) and visual acuity (VA) measurements were performed at baseline and at days 60 and 180. In T-NION, further measurements were achieved at days 240 and 360. Results: At baseline, NT-NION and T-NION patients showed abnormal PERGs and VEPs, and reduced VA, compared to controls. At the end of treatment (days 60 and 240), T-NION patients showed improvement (P <0.01) of PERGs, VEPs parameters and VA, compared to pre-treatment values. After wash out, functional improvements persisted compared to baseline. No changes in NT-NION patients were observed. Conclusions: Our results suggest a beneficial effect of oral Citicoline in NION.

Original languageEnglish
Pages (from-to)465-474
Number of pages10
JournalEuropean Journal of Neurology
Issue number5
Publication statusPublished - May 2008


  • Cytidine-5-diphosphocholine
  • Non-arteritic ischaemic optic neuropathy
  • Pattern-electroretinogram
  • Visual evoked potential

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Neuroscience(all)


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