Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma

Stefania Sorrentino, Cristina Rosanda, Stefano Parodi, Anna Rita Gigliotti, Mirella Pasino, Raffaella Defferrari, Gian Paolo Tonini, Bruno De Bernardi

Research output: Contribution to journalArticlepeer-review


We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number2
Publication statusPublished - Mar 2012


  • bone marrow
  • infant
  • MYCN gene
  • neuroblastoma
  • stage 4
  • stage 4S

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology


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