TY - JOUR
T1 - Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma
AU - Sorrentino, Stefania
AU - Rosanda, Cristina
AU - Parodi, Stefano
AU - Rita Gigliotti, Anna
AU - Pasino, Mirella
AU - Defferrari, Raffaella
AU - Paolo Tonini, Gian
AU - De Bernardi, Bruno
PY - 2012/3
Y1 - 2012/3
N2 - We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
AB - We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
KW - bone marrow
KW - infant
KW - MYCN gene
KW - neuroblastoma
KW - stage 4
KW - stage 4S
UR - http://www.scopus.com/inward/record.url?scp=84857943844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857943844&partnerID=8YFLogxK
M3 - Article
C2 - 22367387
VL - 34
SP - 154
EP - 158
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 2
ER -