Cyto-Morphologic evaluation of bone marrow in infants with disseminated neuroblastoma

Stefania Sorrentino, Cristina Rosanda, Stefano Parodi, Anna Rita Gigliotti, Mirella Pasino, Raffaella Defferrari, Gian Paolo Tonini, Bruno de Bernardi

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Abstract

We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.

Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
DOIs
Publication statusAccepted/In press - Nov 11 2011

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ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Sorrentino, S., Rosanda, C., Parodi, S., Rita Gigliotti, A., Pasino, M., Defferrari, R., Paolo Tonini, G., & de Bernardi, B. (Accepted/In press). Cyto-Morphologic evaluation of bone marrow in infants with disseminated neuroblastoma. Journal of Pediatric Hematology/Oncology. https://doi.org/10.1097/MPH.0b013e3182281dc3