Cytochemistry of dipeptidylaminopeptidase IV in T lymphoblastic leukaemia-lymphoma.

R. Invernizzi, O. Perugini, P. De Fazio, F. Bonetti, B. L. Nespoli

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Abstract

The cytochemical distribution of dipeptidylaminopeptidase IV (DAP IV) was studied in 5 cases of T lymphoblastic leukaemic lymphoma and 12 cases of acute T lymphoblastic leukaemia, in order to ascertain differences between the enzyme positivity patterns of T cells at different stages of differentiation. Early thymic phenotype cases were almost completely negative; those of intermediate and mature thymic phenotype showed positivity in various percentages of blasts: either a single coarse granule or many coarse and small granules were detected. In mature phenotype cells a particularly intense DAP IV reaction was observed. In conclusion, our findings suggest that DAP IV reaction could be a useful tool for the cytochemical characterization of T acute leukaemia subtypes.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalHaematologia
Volume22
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology

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    Invernizzi, R., Perugini, O., De Fazio, P., Bonetti, F., & Nespoli, B. L. (1989). Cytochemistry of dipeptidylaminopeptidase IV in T lymphoblastic leukaemia-lymphoma. Haematologia, 22(3), 143-149.