Cytochrome c oxidase during human fetal development

Maurizio Moggio; Nereo Bresolin; Elio Scarpini; Laura Adobbati; Alessandro Prelle; Andrea Gallanti; Luciano Bet; Francesco Fortunato; Giulio Pellegrini; Guglielmo Scarlato

doi:10.1016/0736-5748(89)90040-3

Cytochrome c oxidase during human fetal development

Maurizio Moggio, Nereo Bresolin, Elio Scarpini, Laura Adobbati, Alessandro Prelle, Andrea Gallanti, Luciano Bet, Francesco Fortunato, Giulio Pellegrini, Guglielmo Scarlato

Research output: Contribution to journal › Article › peer-review

Abstract

Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.

Original language	English
Pages (from-to)	5-14
Number of pages	10
Journal	International Journal of Developmental Neuroscience
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0736-5748(89)90040-3
Publication status	Published - 1989

Keywords

Cytochrome c oxidase
human tissues development
mitochondria

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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10.1016/0736-5748(89)90040-3

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Cytochrome c oxidase during human fetal development. / Moggio, Maurizio; Bresolin, Nereo ; Scarpini, Elio; Adobbati, Laura; Prelle, Alessandro; Gallanti, Andrea; Bet, Luciano; Fortunato, Francesco; Pellegrini, Giulio; Scarlato, Guglielmo.

In: International Journal of Developmental Neuroscience, Vol. 7, No. 1, 1989, p. 5-14.

Research output: Contribution to journal › Article › peer-review

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abstract = "Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.",

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AU - Moggio, Maurizio

AU - Bresolin, Nereo

AU - Scarpini, Elio

AU - Adobbati, Laura

AU - Prelle, Alessandro

AU - Gallanti, Andrea

AU - Bet, Luciano

AU - Fortunato, Francesco

AU - Pellegrini, Giulio

AU - Scarlato, Guglielmo

PY - 1989

Y1 - 1989

N2 - Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.

AB - Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.

KW - Cytochrome c oxidase

KW - human tissues development

KW - mitochondria

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Cytochrome c oxidase during human fetal development

Abstract

Keywords

ASJC Scopus subject areas

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