Cytochrome c oxidase during human fetal development

Maurizio Moggio, Nereo Bresolin, Elio Scarpini, Laura Adobbati, Alessandro Prelle, Andrea Gallanti, Luciano Bet, Francesco Fortunato, Giulio Pellegrini, Guglielmo Scarlato

Research output: Contribution to journalArticlepeer-review


Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Issue number1
Publication statusPublished - 1989


  • Cytochrome c oxidase
  • human tissues development
  • mitochondria

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience


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