TY - JOUR
T1 - Cytochrome c oxidase during human fetal development
AU - Moggio, Maurizio
AU - Bresolin, Nereo
AU - Scarpini, Elio
AU - Adobbati, Laura
AU - Prelle, Alessandro
AU - Gallanti, Andrea
AU - Bet, Luciano
AU - Fortunato, Francesco
AU - Pellegrini, Giulio
AU - Scarlato, Guglielmo
PY - 1989
Y1 - 1989
N2 - Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.
AB - Histochemical, biochemical and immunologic analysis of cytochrome c oxidase (COX) in skeletal muscle, heart and kidney during human fetal development was performed. COX histochemical activity was present only in few muscle fibres from the 11th to the 20th week of gestation. At the same developmental stage intrafusal muscle fibres, heart and kidney already showed strong activity. At the 28th week of gestation muscular COX activity was present in about 90% of the fibres. Tissue biochemical analysis confirmed these histochemical findings. Histochemical and biochemical findings compared to the immunocytochemical results and ELISA indicate that COX activity parallels the progressive synthesis of the enzyme in each tissue.
KW - Cytochrome c oxidase
KW - human tissues development
KW - mitochondria
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U2 - 10.1016/0736-5748(89)90040-3
DO - 10.1016/0736-5748(89)90040-3
M3 - Article
C2 - 2540623
AN - SCOPUS:0024534205
VL - 7
SP - 5
EP - 14
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
SN - 0736-5748
IS - 1
ER -