This review aims to provide physicians with a "practical" approach to the study of drug-drug interactions, a field where pharmacological studies and regulatory data exceed clinical evidence. The lack of pharmacoepidemiological studies on patients and populations representative of the clinical setting leaves physicians without valid information on the risk/ benefit ratio when two or more drugs are administered at the same time. The first part of the review deals with cytochrome P450 drug metabolism. Drug oxidation plays a major role in bioavailability and clearance and, because of the inducibility and/or inhibition of the catalytic activity of cytochrome P450 enzymes, this is the factor most frequently responsible for drug interactions. The second part discusses the clinical relevance and transferability of pharmacological information in the light of some examples.
|Translated title of the contribution||Cytochrome P450 and metabolic drug interactions (part I: Pharmacological principles and potential clinical consequences)|
|Number of pages||11|
|Journal||Ricerca e Pratica|
|Publication status||Published - Jul 2004|
ASJC Scopus subject areas