Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients

Gabriella Sozzi, Monica Miozzo, Elda Tagliabue, Carla Calderone, Luciano Lombardi, Silvana Pilotti, Ugo Pastorino, Marco A. Pierotti, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

A cytogenetic analysis was performed on direct preparations and short-term cell cultures of lung tumor and normal bronchial epithelium of 19 patients carrying either a first or a second primary lung cancer. In 9 tumors (6 squamous cell carcinomas, 1 adenocarcinoma, 1 mucoepidermoid carcinoma, and 1 small cell lung carcinoma) successfully analyzed, pseudodiploid and hyperdiploid karyotypes were observed with a heterogeneous pattern of chromosome abnormalities but with a consistent involvement (5 cases) of the short or the long arm of chromosome 3. The normal bronchial epithelial cells had a normal karyotype in 11 patients, whereas in 6 patients clonal and nonclonal chromosomal abnormalities were observed. Involvement of chromosome 7 was present in 4 cases. In addition, overexpression of the growth factor receptors, epidermal growth factor receptor and HER-2/neu, was found in 9 of 18 tumors and in 6 of 13 bronchial epithelium samples. These findings suggest that early genetic lesions could be present in the normal bronchial epithelial cells that are the target of further complex and multiple genetic changes occurring during the pathogenesis of lung cancer.

Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalCancer Research
Volume51
Issue number1
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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