Abstract
Malignant trophoblastic cells from a case of choriocarcinoma were cytogenetically investigated by direct analysis of fresh tissue from the tumor. To our knowledge, previous cytogenetic studies have been performed only on established cell lines. In this study, 54 metaphases were observed, of which 41 were fully karyotyped. Three chromosomally abnormal lines were identified. In all of them, trisomy 3 and 10, a supernumerary isochromosome 1q,i(1)(q10), an i(8)(q10) replacing one chromosome 8, and a marker chromosome were observed. In addition, involvement of chromosome 12 was observed in two of the three lines, trisomic in one and an i(12)(q10) in the other.
| Original language | English |
|---|---|
| Pages (from-to) | 149-151 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 68 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 15 1993 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
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Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma. / Bettio, Daniela; Giardino, Daniela; Rizzi, Nicoletta; Simoni, Giuseppe.
In: Cancer Genetics and Cytogenetics, Vol. 68, No. 2, 15.07.1993, p. 149-151.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma
AU - Bettio, Daniela
AU - Giardino, Daniela
AU - Rizzi, Nicoletta
AU - Simoni, Giuseppe
PY - 1993/7/15
Y1 - 1993/7/15
N2 - Malignant trophoblastic cells from a case of choriocarcinoma were cytogenetically investigated by direct analysis of fresh tissue from the tumor. To our knowledge, previous cytogenetic studies have been performed only on established cell lines. In this study, 54 metaphases were observed, of which 41 were fully karyotyped. Three chromosomally abnormal lines were identified. In all of them, trisomy 3 and 10, a supernumerary isochromosome 1q,i(1)(q10), an i(8)(q10) replacing one chromosome 8, and a marker chromosome were observed. In addition, involvement of chromosome 12 was observed in two of the three lines, trisomic in one and an i(12)(q10) in the other.
AB - Malignant trophoblastic cells from a case of choriocarcinoma were cytogenetically investigated by direct analysis of fresh tissue from the tumor. To our knowledge, previous cytogenetic studies have been performed only on established cell lines. In this study, 54 metaphases were observed, of which 41 were fully karyotyped. Three chromosomally abnormal lines were identified. In all of them, trisomy 3 and 10, a supernumerary isochromosome 1q,i(1)(q10), an i(8)(q10) replacing one chromosome 8, and a marker chromosome were observed. In addition, involvement of chromosome 12 was observed in two of the three lines, trisomic in one and an i(12)(q10) in the other.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027303940&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(93)90014-D
DO - 10.1016/0165-4608(93)90014-D
M3 - Article
C2 - 8353808
AN - SCOPUS:0027303940
VL - 68
SP - 149
EP - 151
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -