Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma

Daniela Bettio, Daniela Giardino, Nicoletta Rizzi, Giuseppe Simoni

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Malignant trophoblastic cells from a case of choriocarcinoma were cytogenetically investigated by direct analysis of fresh tissue from the tumor. To our knowledge, previous cytogenetic studies have been performed only on established cell lines. In this study, 54 metaphases were observed, of which 41 were fully karyotyped. Three chromosomally abnormal lines were identified. In all of them, trisomy 3 and 10, a supernumerary isochromosome 1q,i(1)(q10), an i(8)(q10) replacing one chromosome 8, and a marker chromosome were observed. In addition, involvement of chromosome 12 was observed in two of the three lines, trisomic in one and an i(12)(q10) in the other.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume68
Issue number2
DOIs
Publication statusPublished - Jul 15 1993

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Isochromosomes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 8
Choriocarcinoma
Trisomy
Metaphase
Genetic Markers
Cytogenetics
Chromosome Aberrations
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma. / Bettio, Daniela; Giardino, Daniela; Rizzi, Nicoletta; Simoni, Giuseppe.

In: Cancer Genetics and Cytogenetics, Vol. 68, No. 2, 15.07.1993, p. 149-151.

Research output: Contribution to journalArticle

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