Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland

Elisabetta Magrini, Antonella Pragliola, Anna Farnedi, Christine M. Betts, Roberto Cocchi, Maria P. Foschini

Research output: Contribution to journalArticle

Abstract

Myoepithelial cell carcinoma (MCC) of the salivary gland is a rare entity. Here, we describe the karyotype of MCC. The patient was a 53-year-old man, with a rapidly growing lesion of the palate. Despite complete surgical excision, radio- and chemotherapy, the lesion rapidly harboured local and distant metastases leading to the death of the patient, 4 months after the diagnosis. On histological and ultrastructural examination, the primary tumour and the related metastases were composed of oval and spindle cells, with features of myoepithelial cell differentiation reported in the literature. Cytogenetic analysis showed a composite karyotype in the primary tumour: 45∼46,XY, +3[cp3]/ 44∼45,XY, -17[cp4]/ 46,XY[5]. The lymph-node metastasis was near-triploid and showed a complex karyotype. Our cytogenetic data differ from those described in benign or slowly growing salivary gland tumours showing myoepithelial cell differentiation. It is suggested that highly aggressive tumours might follow a different pathway of malignant transformation.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalVirchows Archiv
Volume444
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Chromosome 17
  • Cytogenetic analysis
  • Karyotype
  • Myoepithelial cell carcinoma
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland'. Together they form a unique fingerprint.

  • Cite this

    Magrini, E., Pragliola, A., Farnedi, A., Betts, C. M., Cocchi, R., & Foschini, M. P. (2004). Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland. Virchows Archiv, 444(1), 82-86. https://doi.org/10.1007/s00428-003-0909-9