Cytogenetic and clinical investigations in 76 cases with therapy-related leukemia and myelodysplastic syndrome

Alessandra Iurlo, Cristina Mecucci, Angeline Van Orshoven, Jean Louis Michaux, Marc Boogaerts, Lucien Noens, André Bosly, Andries Louwagie, Herman Van Den Berghe

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical, cytomorphologic, and cytogenetic investigations were carried out in a series of 76 secondary MDS and ANLL. Chromosome abnormalities were more frequent in patients with a history of multiple myeloma or macroglobulinemia (92%) and myeloproliferative disorders (82%) than in patients with previous breast cancer (40%). The secondary hematologic malignancies were mostly a trilineage bone marrow disorder. The most commonly found cytogenetic anomaly was monosomy 7, followed by total or partial loss of chromosome 5. In addition six other chromosomes, i.e., chromosome 3, 8, 9, 12, 17, and 21 seemed to be consistently involved in the pathogenetic mechanisms of secondary leukemia and MDS.

Original languageEnglish
Pages (from-to)227-241
Number of pages15
JournalCancer Genetics and Cytogenetics
Volume43
Issue number2
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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