Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas

G. Sozzi, I. Bongarzone, M. Miozzo, C. T. Cariani, P. Mondellini, C. Calderone, S. Pilotti, M. A. Pierotti, G. Della Porta

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Abstract

A combined cytogenetic and molecular analysis was performed on 11 cases of papillary thyroid carcinoma. A simple karyotypic abnormality was detected in five tumors, whereas six had no apparent chromosome change. In four of five rearranged cases the presence of a specific chromosomal abnormality involving chromosome 10 (cases 1 and 2) and chromosome 1 (cases 3 and 4) was associated with the rearrangement of two protooncogenes: RET and NTRKI (formerly trk), respectively, with different donor genes. Moreover, the chromosomal localization of the involved genes and the type of chromosomal change observed suggested that RET and NTRKI activation occurred by intrachromosomal rearrangements. The six cases with normal karyotype did not show RET or NTRKI activation. These findings suggest that a combined cytogenetic and molecular approach would be useful in understanding the pathogenesis of thyroid neoplasia.

Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalGenes Chromosomes and Cancer
Volume5
Issue number3
DOIs
Publication statusPublished - 1992

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Cytogenetics
Molecular Biology
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Karyotype
Chromosome Aberrations
Genes
Neoplasms
Thyroid Gland
Chromosomes
Papillary Thyroid cancer

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. / Sozzi, G.; Bongarzone, I.; Miozzo, M.; Cariani, C. T.; Mondellini, P.; Calderone, C.; Pilotti, S.; Pierotti, M. A.; Della Porta, G.

In: Genes Chromosomes and Cancer, Vol. 5, No. 3, 1992, p. 212-218.

Research output: Contribution to journalArticle

Sozzi, G, Bongarzone, I, Miozzo, M, Cariani, CT, Mondellini, P, Calderone, C, Pilotti, S, Pierotti, MA & Della Porta, G 1992, 'Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas', Genes Chromosomes and Cancer, vol. 5, no. 3, pp. 212-218. https://doi.org/10.1002/gcc.2870050307
Sozzi, G. ; Bongarzone, I. ; Miozzo, M. ; Cariani, C. T. ; Mondellini, P. ; Calderone, C. ; Pilotti, S. ; Pierotti, M. A. ; Della Porta, G. / Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. In: Genes Chromosomes and Cancer. 1992 ; Vol. 5, No. 3. pp. 212-218.
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AU - Calderone, C.

AU - Pilotti, S.

AU - Pierotti, M. A.

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