Cytogenetic findings in 20 melanomas

P. Grammatico, C. Catricalà, C. Potenza, A. Amantea, M. Roccelia, F. Roccelia, L. Elbenachutz, G. Del Porto

Research output: Contribution to journalArticlepeer-review

Abstract

We report cytogenetic studies performed on 20 patients with cutaneous malignant meianoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, In order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalMelanoma Research
Volume3
Issue number3
Publication statusPublished - 1993

Keywords

  • chromosomal marker
  • Clinical characterization
  • Cytogenetics
  • Melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology
  • Oncology

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