Cytogenetic findings in a case of dedifferentiated chondrosarcoma

Laura Casorzo, Laura Chiecchio, Alberto Pisacane, Sergio Fumero, Federico Canavese, Bruno Torchio, Mauro Risio

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic analysis of a case of dedifferentiated chondrosarcoma with a malignant fibrous histiocytoma (MFH) component revealed a near-triploid karyotype with multiple copies of chromosome 7, deletion of chromosome arm 9p, and a derivative chromosome 19 [add(19p)] in each metaphase. Whereas numerical anomalies of chromosome 7 have been frequently reported in chondrosarcoma, deletion 9p and add (19p) have been observed in MFH. A putative MFH tumor suppressor gene could be present in a critical region on chromosome bands 9p21∼p22.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume144
Issue number1
DOIs
Publication statusPublished - Jul 1 2003

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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