Cytogenetic heterogeneity in a second primary radiation-induced bladder carcinoma: Ten karyotypically unrelated clones

Imad Fadl-Elmula, Laura Bonaldi, Ludmila Gorunova, Nils Mandahl, Peter Elfving, Sverre Heim

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic analysis of a transitional cell carcinoma (TCC) of the bladder, the tumor having developed 32 years after the patient received pelvic irradiation and interstitial radium implantation for an endometrial carcinoma, revealed the presence of 10 cytogenetically abnormal, unrelated clones. Although the tumor was poorly differentiated, all clones were pseudo- or near-diploid with rather simple balanced or unbalanced structural rearrangements or both. The chromosomes involved in structural changes more than once were chromosomes 8, 9, and 11, which were rearranged in three clones, and chromosomes 3 and 17, both rearranged in two clones. No previous TCC of the bladder with cytogenetically unrelated clones has been reported, nor has any such radiation-induced tumor with chromosomal abnormalities been described. The distinct karyotypic and clonal pattern of the case presented here is probably indicative of a carcinogenic field effect due to the previous pelvic irradiation. Postradiation bladder carcinomas thus seem to be distinct cytogenetically in addition to their known unique etiological and clinical features.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume105
Issue number2
DOIs
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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