Cytogenetic instability in a family with gastric cancer recurrence

Roberto Di Lernia, Ivana Magnani, Luisa Doneda, Renato Rizzi, Lidia Larizza

Research output: Contribution to journalArticlepeer-review


An index case with a congenital malformation syndrome enabled detection of a family that had a previous history of spontaneous abortuses and recurrence of neoplasia through three generations. Cytogenetic analysis performed on lymphocytes from 11 subjects in the second and third generation showed karyotypic alterations in both tumor bearers and apparently normal subjects. Chromosome variations consisted of: a) spontaneous chromosome fragility; b) chromosome translocations; c) polymorphisms in the heterochromatic regions in chromosomes Y, #1, #16, #22. The inheritance pattern of all chromosome rearrangements and heteromorphisms observed was established starting with the second generation, and the contribution of specific individuals was identified. Although the relationship between chromosomal instability and predisposition to gastric cancer does not appear to be coincidental, no specific chromosome alteration in normal somatic cells was shared by all members of the family who developed or are at risk of developing tumors.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalCancer Genetics and Cytogenetics
Issue number2
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology


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