Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma

Gabriella Sozzi, Maria Grazia Bertoglio, Silvana Pilotti, Franco Rilke, Marco A. Pierotti, Giuseppe Della Porta

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Direct preparations of five primary and metastatic neuroendocrine Merkel cell carcinomas of the skin were analyzed using a G-banding technique. A recurrent structural abnormality was a rearranged chromosome #1 with involvement of p and q arms. In two cases this rearrangement appeared as a unique structural cytogenetic change. Evidence for clonal origin and karyotypic stability of this tumor was suggested by the occurrence of the same karyotypic changes in two metachronous metastases and in primary and metastatic tumor specimens of two different patients. The bands involved in rearrangements could be of significance in the molecular process of the neoplastic transformation of Merkel tumor because genes relevant to the differentiation of neural crest-derived tissue have been mapped in those regions.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume30
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Merkel Cell Carcinoma
Neuroendocrine Carcinoma
Neuroendocrine Cells
Cytogenetics
Neoplastic Processes
Neoplasms
Neural Crest
Chromosomes, Human, Pair 1
Neoplasm Metastasis
Skin
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma. / Sozzi, Gabriella; Bertoglio, Maria Grazia; Pilotti, Silvana; Rilke, Franco; Pierotti, Marco A.; Porta, Giuseppe Della.

In: Cancer Genetics and Cytogenetics, Vol. 30, No. 1, 1988, p. 151-158.

Research output: Contribution to journalArticle

Sozzi, Gabriella ; Bertoglio, Maria Grazia ; Pilotti, Silvana ; Rilke, Franco ; Pierotti, Marco A. ; Porta, Giuseppe Della. / Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 30, No. 1. pp. 151-158.
@article{db7bbc3220e94c28ae461a4e0c5afb06,
title = "Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma",
abstract = "Direct preparations of five primary and metastatic neuroendocrine Merkel cell carcinomas of the skin were analyzed using a G-banding technique. A recurrent structural abnormality was a rearranged chromosome #1 with involvement of p and q arms. In two cases this rearrangement appeared as a unique structural cytogenetic change. Evidence for clonal origin and karyotypic stability of this tumor was suggested by the occurrence of the same karyotypic changes in two metachronous metastases and in primary and metastatic tumor specimens of two different patients. The bands involved in rearrangements could be of significance in the molecular process of the neoplastic transformation of Merkel tumor because genes relevant to the differentiation of neural crest-derived tissue have been mapped in those regions.",
author = "Gabriella Sozzi and Bertoglio, {Maria Grazia} and Silvana Pilotti and Franco Rilke and Pierotti, {Marco A.} and Porta, {Giuseppe Della}",
year = "1988",
doi = "10.1016/0165-4608(88)90104-5",
language = "English",
volume = "30",
pages = "151--158",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma

AU - Sozzi, Gabriella

AU - Bertoglio, Maria Grazia

AU - Pilotti, Silvana

AU - Rilke, Franco

AU - Pierotti, Marco A.

AU - Porta, Giuseppe Della

PY - 1988

Y1 - 1988

N2 - Direct preparations of five primary and metastatic neuroendocrine Merkel cell carcinomas of the skin were analyzed using a G-banding technique. A recurrent structural abnormality was a rearranged chromosome #1 with involvement of p and q arms. In two cases this rearrangement appeared as a unique structural cytogenetic change. Evidence for clonal origin and karyotypic stability of this tumor was suggested by the occurrence of the same karyotypic changes in two metachronous metastases and in primary and metastatic tumor specimens of two different patients. The bands involved in rearrangements could be of significance in the molecular process of the neoplastic transformation of Merkel tumor because genes relevant to the differentiation of neural crest-derived tissue have been mapped in those regions.

AB - Direct preparations of five primary and metastatic neuroendocrine Merkel cell carcinomas of the skin were analyzed using a G-banding technique. A recurrent structural abnormality was a rearranged chromosome #1 with involvement of p and q arms. In two cases this rearrangement appeared as a unique structural cytogenetic change. Evidence for clonal origin and karyotypic stability of this tumor was suggested by the occurrence of the same karyotypic changes in two metachronous metastases and in primary and metastatic tumor specimens of two different patients. The bands involved in rearrangements could be of significance in the molecular process of the neoplastic transformation of Merkel tumor because genes relevant to the differentiation of neural crest-derived tissue have been mapped in those regions.

UR - http://www.scopus.com/inward/record.url?scp=0023854206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023854206&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(88)90104-5

DO - 10.1016/0165-4608(88)90104-5

M3 - Article

VL - 30

SP - 151

EP - 158

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -