Cytogenetic studies in venous tissue from patients with varicose veins

Susi Scappaticci, Elena Capra, Michela Cortinovis, Renato Cortinovis, Eloisa Arbustini, Marta Diegoli, Marco Fraccaro

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic investigation of primary cell cultures from fragments of varicose veins of seven patients with familial varicosity and seven patients with the sporadic type revealed the presence of metaphases with structural abnormalities, clonal trisomies of chromosomes 7, 12, and 18, and monosomy of chromosome 14 only in cases with the familial type, while the sporadic cases had no similar chromosome aberrations. The immunophenotypical results are consistent with fibroblast lineage of the cultured cells. These results suggest that karyotypic variations in familial varicose vein tissue cultures could in some way be associated either with the genotypic constitution responsible for the familial type or a longer duration of disease on average than those with sporadic varicosities.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume75
Issue number1
DOIs
Publication statusPublished - Jul 1 1994

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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