TY - JOUR
T1 - Cytogenetic studies in venous tissue from patients with varicose veins
AU - Scappaticci, Susi
AU - Capra, Elena
AU - Cortinovis, Michela
AU - Cortinovis, Renato
AU - Arbustini, Eloisa
AU - Diegoli, Marta
AU - Fraccaro, Marco
PY - 1994/7/1
Y1 - 1994/7/1
N2 - Cytogenetic investigation of primary cell cultures from fragments of varicose veins of seven patients with familial varicosity and seven patients with the sporadic type revealed the presence of metaphases with structural abnormalities, clonal trisomies of chromosomes 7, 12, and 18, and monosomy of chromosome 14 only in cases with the familial type, while the sporadic cases had no similar chromosome aberrations. The immunophenotypical results are consistent with fibroblast lineage of the cultured cells. These results suggest that karyotypic variations in familial varicose vein tissue cultures could in some way be associated either with the genotypic constitution responsible for the familial type or a longer duration of disease on average than those with sporadic varicosities.
AB - Cytogenetic investigation of primary cell cultures from fragments of varicose veins of seven patients with familial varicosity and seven patients with the sporadic type revealed the presence of metaphases with structural abnormalities, clonal trisomies of chromosomes 7, 12, and 18, and monosomy of chromosome 14 only in cases with the familial type, while the sporadic cases had no similar chromosome aberrations. The immunophenotypical results are consistent with fibroblast lineage of the cultured cells. These results suggest that karyotypic variations in familial varicose vein tissue cultures could in some way be associated either with the genotypic constitution responsible for the familial type or a longer duration of disease on average than those with sporadic varicosities.
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U2 - 10.1016/0165-4608(94)90211-9
DO - 10.1016/0165-4608(94)90211-9
M3 - Article
C2 - 8039160
AN - SCOPUS:0028015658
VL - 75
SP - 26
EP - 30
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -