Cytogenetics of multiple endocrine neoplasia syndromes. I. Two different, unique clonal chromosome changes in a medullary thyroid carcinoma and in a C-cell thyroid hyperplasia

Susi Scappaticci, Gianluigi Arrigoni, Elena Capra, Paola Maraschio, Marco Fraccaro

Research output: Contribution to journalArticle

Abstract

In short-term cultures of tumor tissue from a medullary thyroid carcinoma (MTC), we found a large clone of cells with a balanced translocation t(9;12)(p24;q22). A large clone with a balanced translocation t(10;16)(p11;q24) was also found in cultures from a C-cell thyroid hyperplasia. No clearcut evidence for chromosome instability was observed in the lymphocytes of the two patients. The mother of the first patient died of MTC; two relatives of the second patient had MTC and one of them had pheochromocytoma. These findings classify the two subjects as MEN 2A patients with different phenotypic expression but with the same type of chromosomal abnormality.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume59
Issue number1
DOIs
Publication statusPublished - 1992

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Multiple Endocrine Neoplasia
Cytogenetics
Hyperplasia
Thyroid Gland
Chromosomes
Clone Cells
Multiple Endocrine Neoplasia Type 2a
Chromosomal Instability
Pheochromocytoma
Chromosome Aberrations
Mothers
Lymphocytes
Medullary Thyroid cancer
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetics of multiple endocrine neoplasia syndromes. I. Two different, unique clonal chromosome changes in a medullary thyroid carcinoma and in a C-cell thyroid hyperplasia. / Scappaticci, Susi; Arrigoni, Gianluigi; Capra, Elena; Maraschio, Paola; Fraccaro, Marco.

In: Cancer Genetics and Cytogenetics, Vol. 59, No. 1, 1992, p. 51-53.

Research output: Contribution to journalArticle

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