Cytoimmunologic monitoring in heart transplant patients

G. Ippoliti, A. Gavazzi, G. Bajani, B. Rovati, C. Campana, D. Arrigoni, L. Martinelli, G. Minzioni, A. Graffigna, M. Vigano

Research output: Contribution to journalArticlepeer-review


Cytoimmunologic monitoring (CIM) has been described as a simple and reliable method for detecting an allograft rejection following heart transplant. This method is based on the presence of recirculating sensitized lymphocytes from the transplant, and thus it is possible to identify activated lymphocytes in peripheral blood. Our experience in 41 episodes clearly confirms what was previously reported by others. Thus, CIM may be considered a reliable method in monitoring heart transplant patients both in diagnosis of acute rejection and infectious episodes. We think that using a panel of monoclonal antibodies to early antigen activation may be useful in identifying the beginning of cellular activation, before any morphologic changes are present.

Original languageEnglish
Pages (from-to)770-771
Number of pages2
JournalTransplantation Proceedings
Issue number1 SUPPL. 1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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