Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori

R. Monno, E. Ierardi, I. Munno, C. Marcuccio, M. A. Valenza, M. Margiotta, A. Francavilla

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Helicobacter pylori causes chronic gastritis and duodenal ulcer disease. In addition, H. pylori gastritis has been linked to chronic erosions of the gastric mucosa. Whether H. pylori-positive patients with evidence of antral chronic erosions are associated with the severity of inflammation in terms of IL-6, TNF-α and IFN-γ production in the gastric mucosa and with epithelial proliferative response, was investigated. The results have shown that mucosal levels of IL-6 are significantly higher in patients with H. pylori-associated gastritis than in the control group. No difference was found in the mucosal levels of the cytokines IL-6, TNF-α and IFN-γ in H. pylori-positive patients with or without erosions which were associated with the degree of gastritis but not with the density of H. pylori. An increase of cell proliferation was also found in H. pylori-infected mucosa in patients with chronic erosions in comparison with H. pylori-positive patients without chronic erosions. It is suggested that if H. pylori-positive patients with chronic erosions are infected with particularly virulent strains then the result may be a more marked injury of the mucosa with a consequent epithelial hyperproliferation, but this remains to be established.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalBiomedical Letters
Volume55
Issue number218
Publication statusPublished - 1997

Fingerprint

Helicobacter pylori
Erosion
Mucous Membrane
Cytokines
Gastritis
Interleukin-6
Gastric Mucosa
Cell proliferation
Duodenal Diseases
Antral
Duodenal Ulcer
Cell Proliferation
Inflammation
Control Groups
Wounds and Injuries

Keywords

  • Chronic erosions
  • Cytokines
  • Epithelial proliferation
  • Helicobacter pylori

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Monno, R., Ierardi, E., Munno, I., Marcuccio, C., Valenza, M. A., Margiotta, M., & Francavilla, A. (1997). Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori. Biomedical Letters, 55(218), 105-113.

Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori. / Monno, R.; Ierardi, E.; Munno, I.; Marcuccio, C.; Valenza, M. A.; Margiotta, M.; Francavilla, A.

In: Biomedical Letters, Vol. 55, No. 218, 1997, p. 105-113.

Research output: Contribution to journalArticle

Monno, R, Ierardi, E, Munno, I, Marcuccio, C, Valenza, MA, Margiotta, M & Francavilla, A 1997, 'Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori', Biomedical Letters, vol. 55, no. 218, pp. 105-113.
Monno R, Ierardi E, Munno I, Marcuccio C, Valenza MA, Margiotta M et al. Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori. Biomedical Letters. 1997;55(218):105-113.
Monno, R. ; Ierardi, E. ; Munno, I. ; Marcuccio, C. ; Valenza, M. A. ; Margiotta, M. ; Francavilla, A. / Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori. In: Biomedical Letters. 1997 ; Vol. 55, No. 218. pp. 105-113.
@article{564e5af604604f28889f6c3537e785b5,
title = "Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori",
abstract = "Helicobacter pylori causes chronic gastritis and duodenal ulcer disease. In addition, H. pylori gastritis has been linked to chronic erosions of the gastric mucosa. Whether H. pylori-positive patients with evidence of antral chronic erosions are associated with the severity of inflammation in terms of IL-6, TNF-α and IFN-γ production in the gastric mucosa and with epithelial proliferative response, was investigated. The results have shown that mucosal levels of IL-6 are significantly higher in patients with H. pylori-associated gastritis than in the control group. No difference was found in the mucosal levels of the cytokines IL-6, TNF-α and IFN-γ in H. pylori-positive patients with or without erosions which were associated with the degree of gastritis but not with the density of H. pylori. An increase of cell proliferation was also found in H. pylori-infected mucosa in patients with chronic erosions in comparison with H. pylori-positive patients without chronic erosions. It is suggested that if H. pylori-positive patients with chronic erosions are infected with particularly virulent strains then the result may be a more marked injury of the mucosa with a consequent epithelial hyperproliferation, but this remains to be established.",
keywords = "Chronic erosions, Cytokines, Epithelial proliferation, Helicobacter pylori",
author = "R. Monno and E. Ierardi and I. Munno and C. Marcuccio and Valenza, {M. A.} and M. Margiotta and A. Francavilla",
year = "1997",
language = "English",
volume = "55",
pages = "105--113",
journal = "Biomedical Letters",
issn = "0961-088X",
publisher = "University of Cambridge",
number = "218",

}

TY - JOUR

T1 - Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori

AU - Monno, R.

AU - Ierardi, E.

AU - Munno, I.

AU - Marcuccio, C.

AU - Valenza, M. A.

AU - Margiotta, M.

AU - Francavilla, A.

PY - 1997

Y1 - 1997

N2 - Helicobacter pylori causes chronic gastritis and duodenal ulcer disease. In addition, H. pylori gastritis has been linked to chronic erosions of the gastric mucosa. Whether H. pylori-positive patients with evidence of antral chronic erosions are associated with the severity of inflammation in terms of IL-6, TNF-α and IFN-γ production in the gastric mucosa and with epithelial proliferative response, was investigated. The results have shown that mucosal levels of IL-6 are significantly higher in patients with H. pylori-associated gastritis than in the control group. No difference was found in the mucosal levels of the cytokines IL-6, TNF-α and IFN-γ in H. pylori-positive patients with or without erosions which were associated with the degree of gastritis but not with the density of H. pylori. An increase of cell proliferation was also found in H. pylori-infected mucosa in patients with chronic erosions in comparison with H. pylori-positive patients without chronic erosions. It is suggested that if H. pylori-positive patients with chronic erosions are infected with particularly virulent strains then the result may be a more marked injury of the mucosa with a consequent epithelial hyperproliferation, but this remains to be established.

AB - Helicobacter pylori causes chronic gastritis and duodenal ulcer disease. In addition, H. pylori gastritis has been linked to chronic erosions of the gastric mucosa. Whether H. pylori-positive patients with evidence of antral chronic erosions are associated with the severity of inflammation in terms of IL-6, TNF-α and IFN-γ production in the gastric mucosa and with epithelial proliferative response, was investigated. The results have shown that mucosal levels of IL-6 are significantly higher in patients with H. pylori-associated gastritis than in the control group. No difference was found in the mucosal levels of the cytokines IL-6, TNF-α and IFN-γ in H. pylori-positive patients with or without erosions which were associated with the degree of gastritis but not with the density of H. pylori. An increase of cell proliferation was also found in H. pylori-infected mucosa in patients with chronic erosions in comparison with H. pylori-positive patients without chronic erosions. It is suggested that if H. pylori-positive patients with chronic erosions are infected with particularly virulent strains then the result may be a more marked injury of the mucosa with a consequent epithelial hyperproliferation, but this remains to be established.

KW - Chronic erosions

KW - Cytokines

KW - Epithelial proliferation

KW - Helicobacter pylori

UR - http://www.scopus.com/inward/record.url?scp=0031515979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031515979&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 105

EP - 113

JO - Biomedical Letters

JF - Biomedical Letters

SN - 0961-088X

IS - 218

ER -