Cytokine expression and epithelial proliferation in chronic erosions of the antral mucosa associated with Helicobacter pylori

R. Monno, E. Ierardi, I. Munno, C. Marcuccio, M. A. Valenza, M. Margiotta, A. Francavilla

Research output: Contribution to journalArticlepeer-review

Abstract

Helicobacter pylori causes chronic gastritis and duodenal ulcer disease. In addition, H. pylori gastritis has been linked to chronic erosions of the gastric mucosa. Whether H. pylori-positive patients with evidence of antral chronic erosions are associated with the severity of inflammation in terms of IL-6, TNF-α and IFN-γ production in the gastric mucosa and with epithelial proliferative response, was investigated. The results have shown that mucosal levels of IL-6 are significantly higher in patients with H. pylori-associated gastritis than in the control group. No difference was found in the mucosal levels of the cytokines IL-6, TNF-α and IFN-γ in H. pylori-positive patients with or without erosions which were associated with the degree of gastritis but not with the density of H. pylori. An increase of cell proliferation was also found in H. pylori-infected mucosa in patients with chronic erosions in comparison with H. pylori-positive patients without chronic erosions. It is suggested that if H. pylori-positive patients with chronic erosions are infected with particularly virulent strains then the result may be a more marked injury of the mucosa with a consequent epithelial hyperproliferation, but this remains to be established.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalBiomedical Letters
Volume55
Issue number218
Publication statusPublished - 1997

Keywords

  • Chronic erosions
  • Cytokines
  • Epithelial proliferation
  • Helicobacter pylori

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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