Cytokine gene expression in neoplastic B cells from human mantle cell, follicular, and marginal zone lymphomas and in their postulated normal counterparts

Irma Airoldi, Roberta Guglielmino, Fabio Ghiotto, Anna Corcione, Paola Facchetti, Mauro Truini, Vito Pistoia

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines may promote tumor growth by paracrine and/or autocrine pathways. Little information is available because malignant cells differ from their normal counterparts for the cytokine repertoire they express. Here we have investigated by reverse transcription-PCR the expression of 22 cytokine genes in neoplastic B lymphocytes from six patients with mantle cell lymphoma, 10 with follicular lymphoma, and 5 with marginal zone lymphoma and in their normal counterparts, ie., naive, germinal center, and memory B cells, purified from tonsils. The overall profiles of cytokine gene expression in neoplastic B cells and in the corresponding normal B-cell subsets were similar, but some "holes" in the repertoire of malignant versus normal B lymphocytes were detected. Different "hole" combinations were identified consistently in mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma, thus representing molecular fingerprints of each individual lymphoma entity.

Original languageEnglish
Pages (from-to)1285-1290
Number of pages6
JournalCancer Research
Volume61
Issue number4
Publication statusPublished - Feb 15 2001

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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